96134-06-4

Upstream product

• 937-39-3 2-phenylacetylhydrazine 
• 141-43-5 ethanolamine 
• 23288-90-6 2-mercapto-5-benzyl-1,3,4-oxadiazole 
• 15095-41-7 2--dithiocarbazinsaeure-methylester 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 
• 96133-98-1 C₁₁H₁₅N₃OS 

Downstream Products

• 96134-39-3 2-(3-Benzyl-5-methylsulfanyl-[1,2,4]triazol-4-yl)-ethanol 

Relevant academic research and scientific papers

Synthesis of new 5-substituted 1,2,4-triazole-3-thione derivatives

In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyetlhyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10). Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.

Derives de la dihydro-2,4 triazole-1,2,4 thione-3 et de l'amino-2 thiadiazole-1,3,4 a partir de nouvelles thiosemicarbazones d'esters

A new general synthesis of 4,5-disubstituted 2,4-dihydro-1,2,3-triazole-3-thiones is proposed.These heterocycles are obtained by the action of primary amines, aralhydrazines or aroylhydrazines on the thiosemicarbazones of esters.These last compounds are prepared by action of chlorhydrates of iminoesters on thiosemicarbazide in dimethylformamide.These thiosemicarbazones react also with strong acids, acid anhydrides and chlorides; by thermolysis and they give 2-amino-1,3,4-thiadiazole derivatives.Also, two derivatives of 1,2,4-triazolo-1,3,4-thiadiazole have been prepared.