96136-13-9

Usage

InChI:InChI=1/C13H16O3/c1-10(2)8-12(14)13(15)16-9-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3

Upstream product

• 4502-00-5 sodium 4-methyl-2-oxovalerate 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 816-66-0 4-methyl-2-oxopentanoic acid 

Downstream Products

• 130316-50-6 (4S)-benzyl 3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanoate 
• 37755-48-9 benzyl (R)-2-hydroxy-4-methylpentanoate 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 
• 130316-61-9 2-((S)-1-tert-Butoxycarbonyl-3-phenyl-propylamino)-4-methyl-pentanoic acid 
• 130316-64-2 (4S)-3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-65-3 (2R,4S)-3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 130316-65-3 (2S,4S)-3-aza-4-(tert-butoxycarbonyl)-2-isobutyl-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 142880-30-6 benzyl E,Z-2-isobutyl-3-(methoxycarbonyl)propenoate 
• 104408-44-8 Z benzyl 3-(ethoxycarbonyl)-2-(2-methylpropyl)butenoate 
• 96136-14-0 N-[2-N-(t-Butyloxycarbonyl)amino-1-(R)-methoxycarbonyl-ethyl]-L-leucine Benzyl ester 

Relevant academic research and scientific papers

Enantioselective Organocatalyzed Consecutive Synthesis of Alkyl 4,5-Dihydrofuran-2-carboxylates from α-Keto Esters and (Z)-β-Chloro-β-nitrostyrenes

Alkyl 4,5-dihydrofuran-2-carboxylates can be efficiently obtained via an enantioselective organocatalyzed consecutive reaction between α-keto esters and (Z)-(2-chloro-2-nitroethenyl)benzenes. The overall sequence combines a (R,R)-TUC-catalyzed Michael addition with a DABCO-promoted intramolecular O-alkylation leading to the title products as single diastereomers with enantiomeric excesses from 86% up to 97%.

Activation of 1,2-keto esters with Takemoto's catalyst toward michael addition to nitroalkenes

When activated with Takemoto's catalyst, 1,2-keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti-adducts in very good yields and high enantiomeric excesses. Copyright

Amino acid derivatives inhibiting extracellular matrix metalloproteinase and TNF alpha release

The invention concerns compounds of general formula (X) in which Y represents in particular —CONHOH, R1represents in particular a C1-C5alkyl group, AA represents an amino acid, or an amino acid sequence, and R3represents in particular a group of formula —NH—(CH2)2—SCH3. The invention also concerns the pharmaceutical compositions containing them, and the methods for obtaining them.

INHIBITORS OF TNF-ALPHA SECRETION

Compounds and methods are disclosed that are useful in inhibiting the TNF-α converting enzyme (TACE) responsible for cleavage of TNF-. alpha. precursor to provide biologically active TNF-α. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.