96150-86-6Relevant academic research and scientific papers
A Synthetic Approach to the Squalestatins and Zaragozic Acids: Introduction of the C5 Stereocentre via an Ester-Enolate Claisen Rearrangement. The X-Ray Crystal Structure of an Intermediate
Gable, Robert W.,McVinish, Leasa M.,Rizzacasa, Mark A.
, p. 1537 - 1544 (2007/10/02)
In an overall plan to synthesize the anti-cholesterol agents the squalestatins and zaragozic acids, introduction of the C5 stereochemistry was achieved via an Ireland-Claisen rearrangement of the allyl ester (7) followed by methylation, which gives the es
The Convergent Synthesis of Polyether Ionophore Antibiotics: The Synthesis of the Monensin Bis(tetrahydrofuran) via the Claisen Rearrangement of an Ester Enolate with a β-Leaving Group
Ireland, Robert E.,Norbeck, Daniel W.
, p. 3279 - 3285 (2007/10/02)
The monensin bis(tetrahydrofuran) 25, a versatile intermediate for the synthesis of polyether ionophore antibiotics, is prepared from D-xylose and D-mannose.In the key step, in situ silylation of an ester enolate with a β-leaving group allows the tetrahyd
