96155-91-8Relevant academic research and scientific papers
Operational control of stereoselectivity during the enzymatic hydrolysis of racemic organophosphorus compounds
Li, Yingchun,Aubert, Sarah D.,Raushel, Frank M.
, p. 7526 - 7527 (2007/10/03)
The wild-type bacterial phosphotriesterase catalyzes the stereoselective hydrolysis of racemic pairs of organophosphorus compounds. The enzymatic stereoselectivity can be substantially enhanced via systematic alteration of the pKa for the leavi
Effect of Basicity on the Decomposition of the Conjugate Base of 4-Nitrophenyl N-aryl-P-phenylphosphonamidates
Bourne, Nicholas,Williams, Andrew
, p. 265 - 268 (2007/10/02)
The hydrolyses at 25 deg C in 50percent ethanol-water and 1M ionic strength of the title compounds in alkaline solutions obey the equation kobs = k0/(1 + Kw/Ka->) where k0 is the rate co
Preparation of 3-substituted cephalosporins
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, (2008/06/13)
There is described a process for preparing an enamine of formula (IX): STR1 where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 are the same or different C1-4 alkyl or C7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): STR2 with an amine of formula HNR5 R6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.
