96166-00-6

Usage

Uses

Used in Organic Synthesis:
5-(benzyloxy)pyridin-2-amine is used as a building block in the synthesis of various organic compounds, contributing to the development of new chemical entities with diverse applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-(benzyloxy)pyridin-2-amine is employed as a key intermediate for the development of new drugs and pharmaceuticals. Its unique structure and functional groups make it a promising candidate for the creation of novel therapeutic agents.
Used in Drug Development:
5-(benzyloxy)pyridin-2-amine is utilized in drug development for its potential applications in treating various medical conditions. Its pharmacological properties are under investigation to explore its efficacy and safety as a component of new medications.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, 5-(benzyloxy)pyridin-2-amine is used as a chemical intermediate for the synthesis of active pharmaceutical ingredients. Its presence in the development pipeline underscores its importance in advancing pharmaceutical formulations and therapies.

InChI:InChI=1/C12H12N2O/c13-12-7-6-11(8-14-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,13,14)

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 1267854-62-5 2-triphenylmethylamino-5-bromopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 1083329-33-2 2-N-(2,5-dimethylpyrrolo)-5-benzyloxypyridine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 55717-46-9 6-aminopyridin-3-ol 
• 1431534-09-6 6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[4,5-b]pyridine 
• 1431534-08-5 N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide 
• 941596-78-7 5-(benzyloxy)-3-bromopyridin-2-amine 
• 1578264-37-5 C₁₉H₁₈N₄O₄ 
• 1578264-29-5 C₁₈H₂₂N₂O₃ 
• 1578264-27-3 C₁₇H₂₀N₂O₃ 
• 1204413-49-9 2-acetamido-5-benzyloxypyridine 
• 630120-99-9 5-(benzyloxy)-2-bromopyridine 
• 96165-99-0 C₄₉H₅₅N₃O₁₂ 

Relevant academic research and scientific papers

AZOLE-SUBSTITUTED PYRIDINE COMPOUND

The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.

METHOD FOR PRODUCING AMINO-HYDROXYPYRIDINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an amino-hydroxypyridinium salt and an amino-hydroxypyridine compound with good yield and without using explosive hydroxylamine. SOLUTION: Provided is a method for producing an amino-hydroxypyridinium salt and an amino-hydroxypyridine compound via an aralkyloxy-pyridine compound represented by a formula (4). (In the formula, PG is a t-butoxycarbonyl group, a diphenylmethyl group, a triphenylmethyl group, a p-methoxyphenyl-diphenylmethyl group or a di(p-methoxyphenyl)phenylmethyl group, R1 is a hydrogen atom, an alkyl group or an alkoxy group, R2 represents a hydrogen atom, an alkyl group or an aryl group, and n is an integer of 1 or 2.) SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). I

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.