5-(benzyloxy)pyridin-2-amine

Base Information

• Chemical Name: 5-(benzyloxy)pyridin-2-amine
• CAS No.: 96166-00-6
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Hs Code.: 2933399090
• Mol file: 96166-00-6.mol

Synonyms:5-phenylmethoxypyridin-2-amine;

Chemical Property of 5-(benzyloxy)pyridin-2-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 374.496oC at 760 mmHg
• PKA: 3.53±0.10(Predicted)
• Flash Point: 180.289oC
• PSA: 48.14000
• Density: 1.18g/cm3
• LogP: 2.82400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5-(Benzyloxy)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)pyridin-2-amine

There total 8 articles about 5-(benzyloxy)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-N-(2,5-dimethylpyrrolo)-5-benzyloxypyridine (1083329-33-2) → 5-phenylmethoxypyridin-2-amine (96166-00-6)

Guidance literature:

With hydroxylamine hydrochloride; water; triethylamine; In ethanol; for 20h; Reflux;

DOI:10.1021/jo801501e

Reference yield: 35.0%

2-amino-5-iodopyridine (20511-12-0) + benzyl alcohol (100-51-6,185532-71-2) → 5-phenylmethoxypyridin-2-amine (96166-00-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; cesium bicarbonate; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo801501e

Reference yield:

2-triphenylmethylamino-5-benzyloxypyridine → 5-phenylmethoxypyridin-2-amine (96166-00-6)

Guidance literature:

With acetic acid; In water; at 70 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-amino-5-iodopyridine

benzyl alcohol

2-N-(2,5-dimethylpyrrolo)-5-benzyloxypyridine

5-bromo-2-pyridylamine

Downstream raw materials:

6-aminopyridin-3-ol

6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[4,5-b]pyridine

N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

5-(benzyloxy)-3-bromopyridin-2-amine

Refernces

• 1、 -. "METHOD FOR PRODUCING AMINO-HYDROXYPYRIDINE COMPOUND". Paragraph 0123. . Retrieved 2017/06/19.
• 2、 Nam, Tae-Gyu,Nara, Susheel J.,Zagol-Ikapitte, Irene,Cooper, Thomas,Valgimigli, Luca,Oates, John A.,Porter, Ned A.,Boutaud, Olivier,Pratt, Derek A.. "Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis". scheme or table. p. 5103 - 5112. Retrieved 2010/04/04.