96184-81-5Relevant articles and documents
Stereoselective total synthesis of (±)-vindeburnol and (±)-16-epi-vindeburnol
Chen, Fener,Chen, Xiangtao,Tang, Pei,Wang, Huijing,Yu, Lei,Zhang, Wen
supporting information, p. 11669 - 11672 (2021/11/12)
A concise stereoselective total synthesis of (±)-vindeburnol and its epimer (±)-16-epi-vindeburnol is presented. This synthetic work features the utilization of Baeyer-Villiger oxidation to install different types of lactone substrate, and a sequence of a
FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 50, (2008/12/07)
The invention features compounds of the general Formula (I): (formula should be inserted here) Compounds of Formula (I) possess unexpectedly high affinity for Alk5 and/or Alk4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.
Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4×-oxocyclohexyl)acetonitrile as the model
Avi, Manuela,Wiedner, Romana M.,Griengl, Herfried,Schwab, Helmut
experimental part, p. 11415 - 11422 (2009/10/17)
Even if biocatalysis is finding increasing application, it still has to gain widespread use in synthetic chemistry. Reasons for this are limitations that enzymes have with regard to substrate range, reaction scope, and insufficient selectivity with unnatural compounds. These shortcomings can be challenged by enzyme and/or substrate engineering, which are employed to alter substrate specificity and enhance the enzyme selectivity toward unnatural substrates. Herein, these two approaches are coupled to improve the hydroxynitrile lyase catalyzed synthesis of 2-hydroxy-(4′-oxocyclohexyl) acetonitrile (4). The ketone functionality is masked as an enol ether, and the oxynitrilase of Hevea brasiliensis is engineered towards this masked substrate to give the product with a high optical purity and to drastically lower the amount of enzyme needed.
