96185-49-8Relevant academic research and scientific papers
The soft nucleophilicity of organotellurolates driving the S N2-type lactone ring-opening reaction
Silva, Márcio S.,Dos Santos, Alcindo A.,Comasseto, Jo?o V.
experimental part, p. 6498 - 6501 (2011/02/23)
Lithium and magnesium organotellurolates were reacted with lactones producing the corresponding tell-urocarboxylic acids. Treatment of the reaction mixture with lithium aluminum hydride allowed the isolation of the corresponding hydroxytellurides in a one-pot operation.
Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells
Engman, Lars,Al-Maharik, Nawaf,McNaughton, Michael,Birmingham, Anne,Powis, Garth
, p. 5091 - 5100 (2007/10/03)
The thioredoxins are small ubiquitous redox proteins with the conserved redox catalytic sequence-Trp-Cys-Gly-Pro-Cys-Lys, where the Cys residues undergo reversible NADPH dependent reduction by selenocysteine containing flavoprotein thioredoxin reductases. Thioredoxin expression is increased in several human primary cancers including lung, colon, cervix, liver, pancreatic, colorectal and squamous cell cancer. The thioredoxin/thioredoxin reductase pathway therefore provides an attractive target for cancer drug development. Organotellurium steroid, lipid, amino acid, nucleic base, and polyamine inhibitors were synthesized on the basis that they might be selectively or differentially incorporated into tumor cells. Some of the newly prepared classes of tellurium-based inhibitors (lipid-like compounds 3b and 3e, amino acid derivative 5b, nucleic base derivative 8b, and polyamine derivatives 14a and 14b) inhibited TrxR/Trx and cancer cell growth in culture with IC 50 values in the low micromolar range.
NUCLEOPHILIC CLEAVAGES OF ESTERS AND ETHERS WITH PHENYLTELLUROTRIMETHYLSILANE
Sasaki, Kazuaki,Aso, Yoshio,Otsubo, Tetsuo,Ogura, Fumio
, p. 453 - 456 (2007/10/02)
The title tellurosilane 1 reacted with esters and ethers in the presence of catalytic zinc iodide under very mild conditions, giving the corresponding products with C-telluration and O-silylation via nucleophilic cleavages of the C-O bonds.
