96212-71-4Relevant academic research and scientific papers
Regio- and Stereodivergent Allylic Reductions of Bicyclic Piperidine Enecarbamate Derivatives
Berti, Francesco,Menichetti, Andrea,Favero, Lucilla,Marchetti, Fabio,Pineschi, Mauro
, p. 12221 - 12228 (2018)
The particular nature of tetrahydropyrido[4,3-e]-1,4,2-dioxazines of type 1 allows the regio- and stereoselective obtainment of substituted N-carbamoyl tetrahydropyridines by common reducing agents. A completely novel, biologically active, bicyclic 1,3-diaza-4-oxa-[3.3.1]-nonene scaffold can be generated by the use of lithium triethylborohydride through unprecedented cascade syn-SN2′ reduction/carbamate reduction/cyclization reactions. The remarkable regioselectivity switches in the allylic reduction process have been rationalized with the aid of computational studies.
1,3-DIAZO-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATING DIABETES
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Page/Page column 19; 21; 22; 23, (2019/01/04)
The present invention relates to compounds having structural formula (I) wherein R1 and R2 are defined as set forth in the description. The invention also relates to a process for the manufacture of the above compounds of formula (I)
Synthesis of bicyclic tetrahydropyridine enamides and enecarbamates by hetero-Cope rearrangement of nitroso cycloadducts
Berti, Francesco,Menichetti, Andrea,Di Bussolo, Valeria,Favero, Lucilla,Pineschi, Mauro
, p. 458 - 468 (2018/06/14)
[Figure not available: see fulltext.] The hetero-Cope rearrangement reactions of inverse carbamate and amide nitroso Diels–Alder cycloadducts with 1,2-dihydropyridines to give novel tetrahydropyridine enamides and enecarbamates have been studied in detail
Some Regio- and Stereochemical Aspects of the Diels-Alder Reaction of Nitrosocarbonyl Compounds with N-Substituted 1,2-Dihydropyridines
Dubey, Sushil K.,Knaus, Edward E.
, p. 2080 - 2086 (2007/10/02)
The intramolecular cycloaddition reaction of N-substituted 1,2-dihydropyridines 1 with (nitrosocarbonyl)benzene, phenyl nitrosoformate, and benzyl nitrosoformate afforded 2,3,5-oxadiazabicyclooct-7-enes 2,5,and 7 and/or 2,3,6-oxadiazabicyclo
