35022-78-7

Basic information

• Product Name: Pyridine, 1-acetyl-1,2-dihydro-2-phenyl-
• CAS NO: 35022-78-7
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol File: 35022-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 1-acetyl-1,2-dihydro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 1-acetyl-1,2-dihydro-2-phenyl-(35022-78-7)
• EPA Substance Registry System: Pyridine, 1-acetyl-1,2-dihydro-2-phenyl-(35022-78-7)

Safety Data

• Hazardous Substances Data: 35022-78-7(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 100-59-4 phenylmagnesium chloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 96212-67-8 5-acetyl-3-benzoyl-6-phenyl-2,3,5-oxadiazabicyclo<2.2.2>oct-7-ene 
• 87843-08-1 1-((3aS,4R,7aR)-3-Benzenesulfonyl-4-phenyl-3a,7a-dihydro-4H-isoxazolo[4,5-c]pyridin-5-yl)-ethanone 
• 96212-74-7 5-acetyl-3-(phenoxycarbonyl)-6-phenyl-2,3,5-oxadiazabicyclo<2.2.2>oct-7-ene 
• 96212-75-8 6-acetyl-3-(phenoxycarbonyl)-5-phenyl-2,3,6-oxadiazabicyclo<2.2.2>oct-7-ene 
• 96212-71-4 rac-1-((4aR,8S,8aS)-3,8-diphenyl-8,8a-dihydropyrido[4,3-e][1,4,2]dioxazine-7(4aH)-yl)ethanone 
• 87843-13-8 1-(3-Methoxy-4-phenyl-3a,7a-dihydro-4H-isoxazolo[4,5-c]pyridin-5-yl)-ethanone 
• 75825-02-4 3,5-diphenyl-6-acetyl-2-oxa-3,6-diazabicyclo<2.2.2>oct-7-ene 
• 96227-29-1 6-acetyl-3-<(benzyloxy)carbonyl>-5-phenyl-2,3,6-oxadiazabicyclo<2.2.2>oct-7-ene 
• 96212-78-1 5-acetyl-3-<(benzyloxy)carbonyl>-6-phenyl-2,3,5-oxadiazabicyclo<2.2.2>oct-7-ene 

Relevant articles and documents

Regioselective Addition of Grignard Reagents to 1-Acylpyridinium Salts. A Convenient Method for the Synthesis of 4-Alkyl(aryl)pyridines

The addition of Grignard reagents to 1-acylpyridinium salts afforded 1-acyl-2-alkyl(aryl)-1,2-dihydropyridines and 1-acyl-4-alkyl(aryl)-1,4-dihydropyridines.The regioselectivity of this reaction, 1,2- vs. 1,4-addition, was examined and found to be dependent upon the structures of the Grignard reagent and the 1-acyl group.Pyridine, 2-picoline, and 3-picoline were studied, and in most cases, significant amounts of 1,4-addition occurred.When a catalytic amount of cuprous iodide was present, nearly exclusive 1,4-addition resulted.The crude 1,4-dihydropyridines were aromatized by heating with sulfur to provide 4-substituted pyridines and picolines in good yield and high isomeric purity.