96225-46-6

Upstream product

• 79463-77-7 N-cyanodiphenylcarbonimidate 
• 6315-89-5 3,4-dimethoxyaniline 

Downstream Products

• 71649-39-3 N-cyano-N'-(3,4-dimethoxyphenyl)-1-piperazinecarboximidamide 
• 160880-34-2 N-(2-aminoethyl)-N'-cyano-N''-(3,4-dimethoxyphenyl)guanidine 
• 700806-01-5 4-[5-amino-3-(3,4-dimethoxy-phenylamino)-[1,2,4]triazol-1-yl]-benzonitrile 
• 700807-18-7 1-(2-chloro-phenyl)-N₃-(3,4-dimethoxy-phenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 700807-15-4 N₃-(3,4-dimethoxy-phenyl)-1-(2-fluoro-phenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 700809-43-4 N₃-(3,4-dimethoxy-phenyl)-1-phenyl-1H-[1,2,4]triazole-3,5-diamine 
• 1028307-57-4 C₁₇H₁₇N₅O₄ 
• 700806-80-0 3-[5-amino-3-(3,4-dimethoxy-phenylamino)-[1,2,4]triazol-1-yl]-benzonitrile 
• 700806-84-4 N₃-(3,4-dimethoxy-phenyl)-1-pyridin-2-yl-1H-[1,2,4]triazole-3,5-diamine 

Relevant academic research and scientific papers

THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

Design, synthesis, and evaluation of a novel dual fms-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia

A high-throughput screen of our compound archive revealed a novel class of dual FMS-like tyrosine kinase 3 (FLT3)/c-KIT inhibitors. With the help of molecular modeling, this class was rapidly optimized for both potency against FLT3 and FLT3/c-KIT and exce

α1-Adrenoceptor blocking activity of some ring-open analogues of prazosin

Synthesis and structural characterization of some ring-open analogues of Prazosin containing either the guanidine substructure or urea-equivalent groups are described. The opening of the pyrimidine ring in Prazosin is very important as far as the affinity for α1-adrenoceptor is concerned. The pA2 values of the ring-open derivatives are 104-105 fold lower than that of the parent. It is probable that the affinity decrease principally reflects a negative influence of the conformational factors in the interaction with the α1-receptor. The derivative 5 containing the guanidine moiety, charged at physiological pH, is as active as the other derivatives containing the uncharged urea-equivalent groups. This behaviour indicates, in this class of compounds, the importance of H-bonding interactions with the receptor. When in the ring-open models the ethanediamino substructure is substituted for the piperazine ring additional decrease in activity occurs.