1028307-57-4Relevant academic research and scientific papers
Design, synthesis, and evaluation of a novel dual fms-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia
Davies, Robert J.,Pierce, Albert C.,Forster, Cornelia,Grey, Ron,Xu, Jinwang,Arnost, Michael,Choquette, Deborah,Galullo, Vincent,Tian, Shi-Kai,Henkel, Greg,Chen, Guanjing,Heidary, David K.,Ma, Joanne,Stuver-Moody, Cameron,Namchuk, Mark
, p. 7184 - 7192 (2011/12/03)
A high-throughput screen of our compound archive revealed a novel class of dual FMS-like tyrosine kinase 3 (FLT3)/c-KIT inhibitors. With the help of molecular modeling, this class was rapidly optimized for both potency against FLT3 and FLT3/c-KIT and exce
