96240-05-0Relevant academic research and scientific papers
CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
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Page/Page column 51, (2008/06/13)
The present invention discloses compounds of Formula I: (I) having 11beta -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
Synthesis of Pyrrolidines and Pyrrolidinones by the Rhodium Complex Catalyzed Cyclization of Unsaturated Amines
Zhou, Jian-Qiang,Alper, Howard
, p. 3328 - 3331 (2007/10/02)
N-Allylic arylamines react with carbon monoxide, sodium borohydride, 2-propanol, and catalytic amounts of the zwitterionic complex η6-C6H6BPh3-Rh(COD)+ (1), to form pyrrolidines as the main products in most cases.Pyrrolidinones result from N-allylic alkylamines.An alternate route to the lactams from N-allylic alkylamines involves synthesis gas instead of CO/NaBH4, together with the dual catalytic system 1/2.Complementary to the N-allylic arylamine route to pyrrolidines with NaBH4 and 1 is the use of synthesis gas, 1, and 1,4-bis(diphenylphosphino)butane.
The Synthesis of 4-Methyl-2-pyrrolidones and 3-Methyl-1-pyrrolidines and Their Mass Spectral Study
Lin, Tay-yean,Kingsbury, Charles A.,Cromwell, Norman H.
, p. 1871 - 1875 (2007/10/02)
A number of 1-alkyl-4-methyl-2-pyrrolidones have been prepared from methyl 4-alkylamino-3-methyl butenoates.The corresponding 1-alkyl-3-methyl-pyrrolidines are obtainable by the reduction of the pyrrolidones with lithium aluminium hydride.The mass spectra
