96251-93-3Relevant academic research and scientific papers
Chelation-directed remote: Meta -C-H functionalization of aromatic aldehydes and ketones
Xie, Shuguang,Li, Sen,Ma, Wenqian,Xu, Xiaohua,Jin, Zhong
supporting information, p. 12408 - 12411 (2019/10/19)
We disclose herein the development of a versatile 1,2-diol directing template for palladium-catalyzed remote meta-C-H functionalization of aromatic aldehydes and ketones. In situ-generation of acetals and ketals, as well as removal afterwards, makes the C-H bond functionalization process more straightforward and efficient. This also represents the first example of chelation-directed meta-C-H functionalization of aromatic aldehydes and ketones.
LA REACTION DE WITTIG-HORNER EN MILIEU HETEROGENE VI. SELECTIVITE DE LA REACTION SUR DES COMPOSES BIFONCTIONNELS
Villieras, Jean,Rambaud, Monique,Graff, Micheline
, p. 53 - 56 (2007/10/02)
Heterogenous media of low basicity (K2CO3 or KHCO3), liquid-liquid or solid-liquid allow the Wittig-Horner reaction of fragile and unprotected aldehydes (hydroxyaldehydes, nitroaldehyde and ketoaldehydes) with excellent yields.The reaction is applied to the synthesis of Royal Jelly acid and Queen Substance of Honey bee.
