96259-62-0Relevant academic research and scientific papers
Synthesis of Isobenzofuranones by Cobalt Catalyzed [2+2+2] Cycloaddition
B?hme, Matthias,Leino, Reko,Méndez-Gálvez, Carolina,Savela, Risto
, (2020/03/13)
Highly regioselective cobalt catalyzed [2+2+2] cycloaddition of diynes and monoynes to afford isobenzofuranones in good yields is described. The reaction proceeds in the presence of cheap and readily available cobalt catalyst with a sterically hindered pyridine-2,6-diimine ligand. Applicability of the method can also be extended to the synthesis of isoindolinones.
Synthesis of phthalides from bis-propargyl ethers: Use of Garratt-Braverman cyclization to construct the phthalans and IBX as a new reagent for subsequent oxidation
Panja, Arpita,Das, Eshani,Maji, Manasi,Basak, Amit
, p. 5986 - 5990 (2015/10/28)
An efficient route to phthalides is described starting from easily available bis-propargyl ethers. The method involves Garratt-Braverman cyclization of the ethers to phthalans which are then efficiently oxidized to the phthalides by iodoxy benzoic acid (IBX) which has been shown to be a superior reagent in terms of yield and reagent stoichiometry for such a transformation in comparison with more commonly used KMnO4/CuSO4 reagent.
