96276-63-0Relevant academic research and scientific papers
Base-Mediated Direct Transformation of N-Propargylamines into 2,3,5-Trisubstituted 1 H-Pyrroles
Mishra, Pawan K.,Verma, Shalini,Kumar, Manoj,Verma, Akhilesh K.
, (2018/11/23)
An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis of structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable and is tolerated by a variety of functional groups. Key intermediates of natural product discoipyrrole C as well as HMG-CoA-reductase inhibitor have been successfully synthesized using developed chemistry. The proposed mechanism was supported by control experiments.
Base-Mediated Direct Transformation of N-Propargylamines into 2,3,5-Trisubstituted 1 H-Pyrroles
Mishra, Pawan K.,Verma, Shalini,Kumar, Manoj,Verma, Akhilesh K.
, p. 7182 - 7185 (2018/11/25)
An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis of structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable and is tolerated by a variety of functional groups. Key intermediates of natural product discoipyrrole C as well as HMG-CoA-reductase inhibitor have been successfully synthesized using developed chemistry. The proposed mechanism was supported by control experiments.
Iron-Catalyzed Radical Cycloaddition of 2H-Azirines and Enamides for the Synthesis of Pyrroles
Zhao, Mi-Na,Ren, Zhi-Hui,Yang, De-Suo,Guan, Zheng-Hui
, p. 1287 - 1290 (2018/03/09)
A novel and efficient Fe-catalyzed radical cycloaddition of 2H-azirines and enamides for the synthesis of substituted pyrroles has been developed. The radical cycloaddition reaction proceeded through a conceptually new Fe(II)-catalyzed homolytic cleavage of C-N bond of 2H-azirines sequential radical cyclization with enamides. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable triaryl-substituted pyrroles in good to high yields under mild reaction conditions.
Studies in microwave mediated solvent-free synthesis of 5-aryl-2,3-diphenylpyrroles from 4-aryl-1,2-diphenyl-2-butene-1,4-diones
Rao, H Surya Prakash,Gorityala, Bala Kishan,Vasantham
, p. 1470 - 1474 (2008/09/18)
4-Aryl-1.2-diphenyl-2-butene-l,4-diones and ammonium formate when irradiated with microwaves furnish 5-aryl-2.3-diphenylpyrroles in good yield under solvent-free conditions.
