96292-86-3Relevant academic research and scientific papers
TRANSFORMATION OF (ISOCHROMAN-1-YL)METHYLENEKETONES TO NAPHTHALENE DERIVATIVES
Yamato, Masatoshi,Hashigaki, Kuniko,Yoshioka, Sabroh,Takeuchi, Yasuo
, p. 1741 - 1750 (2007/10/02)
Treatment of (isochroman-1-yl)methylketones (2c-h) with potassium tert-butoxide gave different naphthalene derivatives (5-14) via novel ring transformation, depending on the presence or absence and the nature of the substituents adjacent to the carbonyl group in 2.
Synthesis and antitumor activity of tropolone derivatives. 2
Yamato,Hashigaki,Ishikawa,Kokubu,Inoue,Tsuruo,Tashiro
, p. 1026 - 1031 (2007/10/02)
Structural requirement for antitumor activity of tropolone derivatives was explored. Isochroman derivatives and α,α-disubstituted compounds were synthesized and their antitumor activities were tested. These nontroponoid derivatives were all inactive, implying that a tropolone ring is essential for the activity. Several compounds related to the monotropolone analogue were synthesized. Among them, three showed significant activity, but their potencies were considerably weaker than those of binary tropolone analogues.
