96301-75-6Relevant academic research and scientific papers
Synthesis of Nitriles from Aldoximes and Primary Amides Using XtalFluor-E
Keita, Massaba,Vandamme, Mathilde,Paquin, Jean-Fran?ois
, p. 3758 - 3766 (2015/11/28)
The dehydration reaction of aldoximes and amides for the synthesis of nitriles using [Et2NSF2]BF4 (XtalFluor-E) is described. Overall, the reaction proceeds rapidly (normally 1 h) at room temperature in an environmentally benign solvent (EtOAc) with only a slight excess of the dehydrating agent (1.1 equiv). A broad scope of nitriles can be prepared, including chiral nonracemic ones. In addition, in a number of cases, further purification of the nitrile after the workup was not required.
REDUCTION OF NITROALKENES WITH STANNOUS CHLORIDE IN NON-ACIDIC AND NON-AQUEOUS MEDIUM. SYNTHESIS OF α-SUBSTITUTED OXIMES
Varma, Rajender S.,Kabalka, George W.
, p. 243 - 244 (2007/10/02)
α, β-Unsaturated nitroalkenes are readily reduced by SnCl2*2H2O in alcoholic media to the α-alkoxy oxime derivatives in high yields.In the presence of ethanethiol, the corresponding α-alkylthio oximes are formed.
MODEL STUDIES FOR THE TOTAL SYNTHESIS OF THE MAYTANSINOIDS BASED ON THE INTRAMOLECULAR NITRILE OXIDE-OLEFIN CYCLOADDITION REACTION
Ko, Soo Sung,Confalone, Pat N.
, p. 3511 - 3518 (2007/10/02)
The macrocyclization of the olefinic nitrile oxide 30 to the ansa-macrolide skeleton 37, a model for a novel approach to the maytansinoids, is described.
