96306-51-3

Upstream product

• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 125734-44-3 4-(hydroxymethyl)benzaldehyde diethyl acetal 

Relevant academic research and scientific papers

Microwave-assisted condensation of kojic acid with aldehydes

Kojic acid derivatives have been prepared in excellent yield by the condensation of two molecules of kojic acid and one molecule of an aldehyde using sodium carbonate as a base under microwave irradiation.

Synthesis and antitumor activity of tropolone derivatives. 2

Structural requirement for antitumor activity of tropolone derivatives was explored. Isochroman derivatives and α,α-disubstituted compounds were synthesized and their antitumor activities were tested. These nontroponoid derivatives were all inactive, implying that a tropolone ring is essential for the activity. Several compounds related to the monotropolone analogue were synthesized. Among them, three showed significant activity, but their potencies were considerably weaker than those of binary tropolone analogues.