96410-41-2

Upstream product

• 96501-80-3 2,4-diisopropoxybenzene-1-carboaldehyde 
• 79128-08-8 1,3-diisopropoxybenzene 

Downstream Products

• 96410-42-3 1,3-bis(isopropyloxy)-4-methoxybenzene 
• 267881-51-6 1-Allyloxy-2,4-diisopropoxybenzene 
• 267881-52-7 5-Allyloxy-2,4-diisopropoxyacetophenone 
• 267881-53-8 2-Allyl-3-benzyloxy-4,6-diisopropoxyacetophenone 
• 267881-54-9 1-(2-Allyl-3-benzyloxy-4,6-diisopropoxyphenyl)ethanol 
• 111786-42-6 2'-hydroxy-2,4-diisopropyloxy-4',5,5',6'-tetramethoxychalcone 
• 96410-43-4 2,4-diisopropyloxy-5-methoxybenzaldehyde 
• 81979-84-2 2′,4′,5,7-tetrahydroxy-5′,6-dimethoxyflavone 
• 77053-48-6 2',4',5-trihydroxy-5',6,7,8-tetramethoxyflavone 
• 96410-39-8 2'-hydroxy-2,4-diisopropyloxy-3',4',5,5',6'-pentamethoxychalcone 
• 96410-40-1 2',4'-diisopropyloxy-5,5',6,7,8-pentamethoxyflavone 
• 96501-87-0 2'-hydroxy-2,4,4',6'-tetraisopropyloxy-5,5'-dimethoxychalcone 
• 96501-88-1 2',4',5,7-tetraisopropyloxy-5',6-dimethoxyflavone 
• 83162-82-7 2',4',5-trihydroxy-5',6,7-trimethoxyflavone 

Relevant academic research and scientific papers

CHRYSOPHAENTIN ANALOGS AND USE THEREOF

Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activitivies that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds.

HISTONE DEMETHYLASE 5 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds or compositions disclosed herein for treating and/or preventing proliferative diseases, cancers, carcinoma lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, leukemia, sarcoma and/or cardiovascular diseases in a subject in need thereof. In certain embodiments, the sarcoma is Ewing's sarcoma. Provided are methods of inhibiting a histone demethylase in a subject and/or in a cell, tissue, or biological sample. In certain embodiments, the histone demethylase is a KDM. In certain embodiments, the KDM is KDM5. In certain embodiments, the biological sample is a cell. In certain embodiments, the biological sample is a tissue.

Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis

Chrysophaentin A is an antimicrobial natural product isolated from the marine alga C. taylori in milligram quantity. Structurally, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubstituted chloroalkenes at its periphery. A concise synthesis of iso-and 9-dechlorochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an oxygen to carbon ring contraction is described. Fluorescent microscopy studies revealed 9-dechlorochrysophaentins leads to inhibition of bacterial cell wall biosynthesis by disassembly of key divisome proteins, the cornerstone to bacterial cell wall biosynthesis and division.

Syntheses of isochromane analogues of the michellamines and korupensamines

Syntheses of the oxygen analogues 6, 7 and 8 of the michellamines 1 and korupensamines 2 are described. Racemic 5-iodo-6,8-dimethoxy-trans-1,3-dimethylisochromane 10 was synthesised in eleven steps from 2,4-dimethoxybenzaldehyde in an overall yield of 51%