96429-72-0

Upstream product

• 50-00-0 formaldehyd 
• 59991-89-8 1,2-dibenzylpropanetriol 
• 20196-71-8 (2S)-2,3-bis(benzyloxy)propanol 
• 20196-70-7 (+)-(R)-2,3-bis(benzyloxy)propanal 
• 20196-69-4 1,2,5,6-tetra-O-benzyl-D-mannitol 

Downstream Products

• 119870-06-3 1-(2,3-Bis-benzyloxy-propoxymethyl)-5-imino-2,5-dihydro-1H-[1,2,3]triazole-4-carboxylic acid amide 
• 119870-10-9 3-(2,3-Bis-benzyloxy-propoxymethyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 96444-55-2 (R)-9-<<2,3-bis(benzyloxy)-1-propoxy>methyl>guanine 
• 132119-60-9 1-(2,3-Bis-benzyloxy-propoxymethyl)-4,5-diphenyl-1H-[1,2,3]triazole 
• 132119-64-3 1-(2,3-Bis-benzyloxy-propoxymethyl)-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester 
• 132119-52-9 1-(2,3-Bis-benzyloxy-propoxymethyl)-5-phenyl-1H-[1,2,3]triazole 
• 132119-53-0 1-(2,3-Bis-benzyloxy-propoxymethyl)-4-phenyl-1H-[1,2,3]triazole 

Relevant academic research and scientific papers

Insight into the recognition mechanism of DNA cytosine-5 methyltransferases (DNMTs) by incorporation of acyclic 5-fluorocytosine (FC) nucleosides into DNA

DNA cytosine-5 methyltransferase (DNMT) catalyzes methylation at the C5 position of cytosine in the CpG sequence in double stranded DNA to give 5-methylCpG (mCpG) in the epigenetic regulation step in human cells. The entire reaction mechanism of DNMT is d

SYNTHESIS AND ANTIVIRAL ACTIVITY OF 1,2,3-TRIAZOLE AND 8-AZAPURINE DERIVATIVES BEARING ACYCLIC SUGARS

A variety of 1,2,3-triazole and 8-azapurine derivatives bearing acyclic sugar moieties were synthesized by the reaction of acyclic sugar azides with α-cyanoacetamide, norbornadiene, and acetylene derivatives, respectively.Antiviral tests of these compound

Guanine derivatives

(S)-9-(2,3-dihydroxy-1-propoxymethyl)guanine has potent antiherpetic activity which is superior to the corresponding racemic mixture or the (R)-enantiomer and also is much more potent than 9-(2-hydroxyethoxymethyl)guanine. Acyl derivatives (prodrugs) of t

Synthesis and antiherpetic activity of (S)-, (R)- and (±)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine

Racemic 9-[2,3-dihydroxy-1-propoxy)methyl]guanine [(±)-iNDG], a new analogue of acyclovir (ACV) and a structural analogue of 2'-nor-2'-deoxyguanosine (2'NDG), was synthesized and found to inhibit the replication of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Subsequently, its optical isomers, (R)- and (S)-iNDG, were prepared from chiral intermediates. The chloromethyl ethers of 1,2-di-O-benzyl-D- and -L-glycerol were made and reacted with tris(trimethylsilyl)guanine to give the 9-alkylated guanines, which were deprotected by catalytic hydrogenolysis. Against HSV-1 and HSV-2 in cell culture, (S)-iNDG was approximately 10- to 25-fold more active than the R enantiomer and had an ED50 comparable to those for ACV and 2'NDG. The inferior activity of (R)-iNDG paralleled the poor inhibition of viral DNA polymerase by its phosphorylation products. In mice infected intraperitoneally or orofacially with HSV-1 or intravaginally with HSV-2, (S)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine [(S)-iNDG] was less efficacious than 2'NDG but comparable to or more active than ACV.