96501-81-4

Upstream product

• 121-33-5 vanillin 
• 824-46-4 methoxyhydroquinone 
• 75-26-3 isopropyl bromide 

Downstream Products

• 792921-41-6 1,4-diisopropoxy-2-methoxy-3-dodec-11-enylbenzene 
• 96410-28-5 2,5,5'-trihydroxy-4',6,7-trimethoxyflavone 
• 96410-27-4 2',5'-diisopropyloxy-4',5,6,7,-tetramethoxyflavone 
• 96410-26-3 2'-hydroxy-2,5-diisopropyloxy-4,4',5',6'-tetramethoxychalcone 
• 1118756-71-0 C₂₉H₅₂O₅Si 
• 1610887-78-9 (3-bromo-2,5-diisopropoxy-6-methoxyphenyl)methanol 
• 1610887-79-0 1-bromo-3-(chloromethyl)-2,5-diisopropoxy-4-methoxybenzene 
• 1610887-80-3 [3-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)prop-1-yne-1-yl]trimethylsilane 
• 1610887-81-4 1-bromo-2,5-diisopropoxy-4-methoxy-3-(prop-2-yne-1-yl)benzene 
• 1610887-82-5 (E)-1-bromo-3-(3-iodo-2-methylallyl)-2,5-diisopropoxy-4-methoxybenzene 
• 1610888-07-7 (3S,4E,6S,7S,9S,11E,13E)-15-(3-bromo-2,5-diisopropoxy-6-methoxyphenyl)-3,7-bis[(tert-butyldimethylsilyl)oxy]-9-hydroxy-4,6,14-trimethylpentadeca-4,11,13-trienamide 
• 1033591-46-6 3-bromo-2,5-diisopropoxy-6-methoxybenzaldehyde 
• 101923-87-9 2'-hydroxy-3,4',6,6'-tetraisopropyloxy-2,5'-dimethoxychalcone 
• 101923-89-1 2-(3,6-Diisopropoxy-2-methoxy-phenyl)-5,7-diisopropoxy-6-methoxy-chromen-4-one 

Relevant academic research and scientific papers

Synthesis of a cytotoxic ansamycin hybrid

The synthesis of a new ansamycin macrolactam derivative that contains an ansa chain based on ansamitocin and an aromatic core related to geldanamycin is reported. The selective introduction of the cyclic carbamoyl group at C7 and C9 relies on a biotransformation using a mutant strain of S. hygroscopicus, the geldanamycin producer. The ansamycin hybrid forms atropisomers that differ in their antiproliferative activity toward cancer cells.

Total synthesis of the Hsp90 inhibitor geldanamycin

(Chemical Equation Presented) An enantioselective synthesis of the Hsp90 inhibitor geldanamycin was achieved in 20 linear steps and 2.0% overall yield from 2-methoxyhydroquinone. The synthesis is highlighted by a regio- and stereoselective hydroboration r