96519-99-2Relevant academic research and scientific papers
Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones
Liu, Yong-Peng,Zhu, Cheng-Jie,Yu, Cun-Cun,Wang, Ai-E,Huang, Pei-Qiang
, p. 7169 - 7174 (2019/11/16)
Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.
IMINOALKYLATION DES ENAMINES AVEC DES NITRILES VIA LE SEL DE NITRILIUM : UNE NUOVELLE METHODE DE SYNTHESE D'ENAMINOCETONES ET DE β-DICETONES
Baudoux, Dominique,Fuks, Robert
, p. 1009 - 1018 (2007/10/02)
The reaction of nitrilium salts with enamines leads to a mixture of enamines 4 and enaminoketones 5 by an iminoalkylation reaction.Partial hydrolysis of 4 with diluted acetic acid leads to the isolation of these new enaminoketones 5 in high yields.Refluxi
