96540-49-7

Upstream product

• 22530-98-9 4-benzyl-dihydro-furan-2-one 
• 96540-34-0 3-ethoxycarbonyl-4-(1-iodobenzyl)-4,5-dihydrofuran-2(3H)-one 
• 96540-42-0 3-carbonyl-4-benzyl-4,5-dihydrofuran-2(3H)-one 
• 96540-38-4 3-ethoxycarbonyl-4-benzyl-4,5-dihydrofuran-2(3H)-one 
• 96540-46-4 4-benzyl-3-phenylthio-4,5-dihydrofuran-2(3H)-one 

Downstream Products

• 16720-76-6 4-(phenylmethyl)-2(5H)-furanone 

Relevant academic research and scientific papers

Synthesis of 4-Alkyl-2(5H)-furanones

An alternative method for the synthesis of 4-alkyl-2(5H)-furanones is described.Intramolecular carbene addition reaction of α-diazo compounds (4) in the presence of rhodium acetate or copper acetylacetonate furnished the bicyclic compounds (5), which were subjected to cyclopropane ring-opening reaction to give the 4-alkyl-4,5-dihydrofuran-2(3H)-ones (6) regioselectively.These compounds (6) were further converted into 4-alkyl-2(5H)-furanones (14) in several steps.Keywords - carbene; intramolecular addition; butenolide; cyclopropanation; ring-opening reaction