96547-08-9Relevant academic research and scientific papers
Synthesis of Some Newer Quinazolinyl-oxadiazoles, Thiosemicarbazides and Thiadiazoles as Pharmacologically Active Agents
Mohan, Rajiv Ravindra,Agarwal, Rajesh,Misra, V. S.
, p. 78 - 82 (2007/10/02)
Fifteen new 3-N,N-dialkylaminomethyl-5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (Va-o) have been synthesised by Mannich reaction on 5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (IVa-c) with different dialkyl amines.N1-(2-Alkyl-1,3-quinazolin-4-yloxymethylcarbonyl)-N4-(p-substituted-phenyl)thiosemicarbazides (VIa-l) have been prepared by condensing (2-alkyl-1,3-quinazolin-4-oxy)acetic acid hydrazides (III) with p-substituted phenyl isothiocyanates.The thiosemicarbazides (VI) undergo cyclisation in AR H2SO4 to furnish 4-(2- alkyl-1,3-quinazolin-4-yloxymethyl)-2-(p-substituted phenylamino)-1,3,4-thiadiazoles (VIIa-l).Compounds V have been found to be nontoxic and CNS stimulants.Most of them show significant protection against carrageenin-induced inflammation.In the anthelmintic activity screening, compounds VI show 21.8-57.4percent clearance of N. brasiliensis, whereas compounds VI and VII are inactive against H. nana.
