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Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-3-chloroaniline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Dye Industry:
In the dye industry, 2-Bromo-3-chloroaniline is utilized as a precursor for the production of dyes, where its unique chemical structure allows for the creation of dyes with distinct color characteristics.
Used in Organic Synthesis:
2-Bromo-3-chloroaniline is employed as a research chemical in organic synthesis, enabling the exploration of novel chemical reactions and the development of new organic compounds with potential applications in various industries.
Used in Medicinal Chemistry:
As a research chemical in medicinal chemistry, 2-Bromo-3-chloroaniline aids in the discovery and optimization of new pharmaceutical agents, contributing to advancements in drug design and development.

InChI:InChI=1/C6H5BrClN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2

Upstream product

• 19128-48-4 2-bromo-1-chloro-3-nitro-benzene 
• 108-42-9 3-chloro-aniline 
• 863870-78-4 O-2-bromo-3-chlorophenyl N,N-diethylcarbamate 
• 1287791-67-6 2-(2-bromo-3-chlorophenoxy)-2-methylpropanamide 
• 1287791-76-7 N-(2-bromo-3-chlorophenyl)-2-hydroxy-2-methylpropanamide 
• 855836-62-3 2-bromo-3-chlorophenol 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 1463053-89-5 tert-butyl (2-bromo-3-chlorophenyl)carbamate 
• 56961-26-3 2-bromo-3-chlorobenzoic acid 

Downstream Products

• 908349-50-8 2-bromo-3-chloro-N-trifluoroacetylaniline 
• 908349-52-0 2-bromo-3-chloro-N-methylaniline 
• 908349-53-1 N-allyl-2-bromo-3-chloro-N-methylaniline 
• 908349-54-2 6-allyl-2-bromo-3-chloro-N-methylaniline 
• 908349-51-9 2-bromo-3-chloro-N-methyl-N-trifluoroacetylaniline 

Relevant academic research and scientific papers

CINNOLINE DERIVATIVES AS AS BTK INHIBITORS

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined in the specification. The compounds are inhibitors of Bruton's tyrosine

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Electrophilic bromination of meta-substituted anilines with N-bromosuccinimide: Regioselectivity and solvent effect

N-Bromosuccinimide-mediated electrophilic aromatic bromination of a series of anilines substituted with an electron-with-drawing group in the meta position was investigated. The regioselectivity of the reaction is markedly dependent on the polarity of the solvent and the bromination reaction can be tuned by appropriate selection of the reaction medium. Georg Thieme Verlag Stuttgart.

Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes

N-Me-anthranylaldoximes possess a hydrogen-bonded pseudocyclic A' ring in place of the typical phenolic A-ring that is characteristic of most estrogen receptor (ER) ligands. We have investigated the role played by substituents introduced into either one o

Copper(I)-Induced Bromo-Hydrogen Exchange of 2,3-Dibromoanilines

The copper(I)-induced bromine-hydrogen exchange reaction of 2,3-dibromoaniline and 5-substituted 2,3-dibromoanilines in the 2-position has been kinetically studied in water-acetic acid-hydrochloric acid medium at 90 deg C.The dehalogenation reaction is of second order, first order in both substrate and Cu+, and may be interpreted as a reductive substitution, composed of two one-electron steps.The 2,3-dibromophenol was only qualitatively investigated, but gave similar results.