96568-07-9 Usage
Uses
Used in Pharmaceutical Industry:
Ethyl 1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate is used as an intermediate in the synthesis of fluoroquinolone-based antibacterial agents. Its unique structure allows it to target and inhibit bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial replication, ultimately leading to the death of the bacteria.
Used in Antimicrobial Research:
In the field of antimicrobial research, Ethyl 1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate serves as a valuable compound for the development of new antibiotics. Its ability to combat drug-resistant bacteria makes it a promising candidate for further investigation and potential clinical applications.
Used in Drug Development:
Ethyl 1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate is utilized in drug development for the creation of novel antibacterial drugs. Its unique chemical properties and potential to overcome bacterial resistance make it an attractive option for pharmaceutical companies seeking to expand their antibiotic portfolios.
Check Digit Verification of cas no
The CAS Registry Mumber 96568-07-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,5,6 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 96568-07:
(7*9)+(6*6)+(5*5)+(4*6)+(3*8)+(2*0)+(1*7)=179
179 % 10 = 9
So 96568-07-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H8ClFN2O3/c13-10-8(14)3-6-9(17)7(12(18)19)4-16(5-1-2-5)11(6)15-10/h3-5H,1-2H2,(H,18,19)
96568-07-9Relevant academic research and scientific papers
Fluoronaphthyridines as Antibacterial Agents. 4. Synthesis and Structure-Activity Relationships of 5-Substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acids
Bouzard, D.,Cesare, P. Di,Essiz, M.,Jacquet, J. P.,Ledoussal, B.,et al.
, p. 518 - 525 (2007/10/02)
A series of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids have been prepared and tested for their in vitro and in vivo antibacterial activities.The 5-methyl group gave better in vitro activity with the 1-cyclopropyl appendage, but poorer activity with the 1-tert-butyl moiety.With the 1-(2,4-difluorophenyl) substitution, the influence of the 7-cycloalkylamino group was determinant: a (3S)-3-aminopyrrolidine was shown to enhance greatly the in vitro and in vivo activity of the 5-methyl derivative.Compound 33 (BMY 43748) was selec ted as a promising candidate for an improved therapeutic agent.
