96648-99-6Relevant academic research and scientific papers
Hexafluoroisopropanol-Mediated Redox-Neutral α-C(sp3)-H Functionalization of Cyclic Amines via Hydride Transfer
Shen, Yao-Bin,Wang, Lin-Xuan,Sun, Yun-Ming,Dong, Feng-Ying,Yu, Liping,Liu, Qing,Xiao, Jian
, p. 1915 - 1926 (2020/02/04)
Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)-H functionalization of cyclic amines via the cascade [1,5]-hydride transfer/cyclization strategy. A wide range of cyclic amines are functionalized
Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines
Shen, Yao-Bin,Li, Long-Fei,Xiao, Ming-Yan,Yang, Jian-Ming,Liu, Qing,Xiao, Jian
, p. 13935 - 13947 (2019/11/11)
The redox-neutral cascade dearomatization of indoles with o-aminobenzaldehydes has been realized via the hydride transfer strategy, achieving the condition- A nd substrate-controlled divergent synthesis of tetrahydroquinoline-fused spiroindolenines. The integration of hydride transfer-involved C(sp3)-H functionalization with dearomatization provides a promising platform for the construction of structurally diverse molecules.
Synthesis of Tetrahydro[1,3,4]triazepines via Redox-Neutral α-C(sp3)-H Amination of Cyclic Amines
An, Xiao-De,Duan, Kang,Li, Xian-Jiang,Yang, Jian-Ming,Lu, Yong-Na,Liu, Qing,Xiao, Jian
, p. 11839 - 11847 (2019/10/02)
A Br?nsted acid-catalyzed α-C(sp3)-H amination of cyclic amines using hydrazines as coupling partners has been reported. This methodology provides a unique protocol to the one-step assembly of tetrahydro[1,3,4]triazepines via [1,5]-hydride tran
Effect of Different Dialkylamino Groups on the Regioselectivity of Lithiation of O-Protected 3-(Dialkylamino)phenols
Skowronska-Ptasinska, Maria,Verboom, Willem,Reinhoudt, David N.
, p. 2690 - 2698 (2007/10/02)
The lithiation of 3-(dialkylamino)phenols (dialkylamino = 1-pyrrolidynyl, 1-piperidinyl, 4-morpholinyl, and dimethylamino) O-protected by a methyl, a methoxymethyl, or a carbamoyl group (X) has been studied.The results demonstrate that the site of lithiation depends on the relative ortho-directing capacities of both the dominant OX and the dialkylamino groups.With the moderate ortho-directing methoxy group the lithiation occurs exclusively (1b and 1c) or predominantly (1a) ortho to both substituents.The site of lithiation of the N,N-dialkyl-3-(methoxymethoxy)anilines 4a-c depends on the solvent used and on the type of dialkylamino group.With a strong ortho-directing group such as carbamoyloxy (9a,b,d) the lithiation takes place at the least hindered ortho position.In the absence of an electrophile the lithiated carbamates 9a,d and 10a,d rearrange stereospecifically to the corresponding benzamides 13a,d and 14a,d, respectively.
