96676-38-9

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 818-38-2 Diethyl glutarate 
• 50-00-0 formaldehyd 
• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 

Downstream Products

• 96676-71-0 1,1,5,5-Tetrakis-(4-methoxyphenyl)-pentan 

Relevant academic research and scientific papers

Reactions of trimethylsilyl-derived iodohydrins with electron-rich π-systems

Reactions of trimethylsilyl-derived iodohydrins of the type R1R2CH-CH(I)OTMS, with electron-rich olefins, and the effects of certain factors on these reactions, were studied. The trimethylsilyl-derived iodohydrins were obtained in situ by reacting R1R2CH-CHO (R1 = R2 = H; R1 = H, R2 = alkyl, phenyl) with TMSI. The corresponding trimethylsilyl enol ether derivatives (R1R2C=CH-OTMS), and 1,1-diarylethylenes were the olefins used. Aldehydes of the type RCH2-CH=O reacted smoothly in the presence of TMSI to yield the condensation product RCH2-CH=C(R)-CH=O. Both RCH(-CH=CAr2)2 and the cyclic acetal 5 were obtained as main products of the RCH=O-TMSI-CH2=CAr2 reaction system, depending on the [RCHO]:[TMSI]:[CH2=CAr2] concentration ratio. The mechanisms of formation for the various main products and by-products are discussed. TMSI substitutes, formed by reacting Me3SiCl with each of several Lewis acids, were also used.