818-38-2

Basic information

• Product Name: Diethyl glutarate
• Synonyms: Propane-1,3-dicarboxylic acid diethyl ester;Diethyl Pentanediate;DIETHYL GLUTARATE, 99+%;Diethylglutarate,98%;Glutaric acid diethyl;Pentanedioic acid diethyl;1,5-diethyl pentanedioate;Diethyl glutarat
• CAS NO: 818-38-2
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.22
• EINECS: 212-451-2
• Product Categories: Acids & Esters;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 818-38-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: -24.1°C
• Boiling Point: 237 °C(lit.)
• Flash Point: 205 °F
• Appearance: /
• Density: 1.022 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0472mmHg at 25°C
• Refractive Index: n20/D 1.423(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1777327
• CAS DataBase Reference: Diethyl glutarate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl glutarate(818-38-2)
• EPA Substance Registry System: Diethyl glutarate(818-38-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 818-38-2(Hazardous Substances Data)

Usage

Chemical Properties

It exists as a liquid between its pour point (-24.1°C) and boiling point (236.6°C). It is soluble in ether and slightly soluble in water and alcohol.

Uses

Diethyl Glutarate has a role as a metabolite. It derives from a glutaric acid (G598000) an organic acid found in human urine which may be used for the detection of metabolic or other health disorders.

Definition

ChEBI: A diester obtained by the formal condensation of carboxy groups of glutaric acid with two molecules of ethanol respectively.

InChI:InChI=1/C9H16O4/c1-3-12-8(10)6-5-7-9(11)13-4-2/h3-7H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 61844-36-8 5-diazo-4-oxo-valeric acid ethyl ester 
• 2121-66-6 tetraethyl 1,1,3,3-propanetetracarboxylate 
• 2049-67-4 diethyl glutaconate 
• 1501-06-0 diethyl 2-acetylglutarate 
• 201230-82-2 carbon monoxide 
• 7425-50-5 ethyl β-iodobutyrate 
• 56703-79-8 Glutaraminsaeureethylester 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 541-41-3 chloroformic acid ethyl ester 
• 1070-62-8 5-ethoxy-5-oxopentanoic acid 
• 1193-55-1 2-methylcyclohexane-1,3-dione 
• 623-73-4 diazoacetic acid ethyl ester 
• 140-88-5 ethyl acrylate 

Downstream Products

• 1070-62-8 5-ethoxy-5-oxopentanoic acid 
• 110-94-1 1,5-pentanedioic acid 
• 111-29-5 1 ,5-pentanediol 
• 3424-60-0 pentanediamide 
• 1508-67-4 glutaric dihydrazide 
• 90535-05-0 3-(2,6-dioxo-cyclohexyl)-propionic acid 
• 100950-64-9 4-(amino-anilino-[1,3,5]triazin-2-yl)-butyric acid ethyl ester 
• 102448-10-2 N²,N^2'-diphenyl-6,6'-propanediyl-bis-[1,3,5]triazine-2,4-diyldiamine 
• 96676-38-9 1,1,5,5-Tetrakis-(4-methoxyphenyl)-penta-1,4-dien 
• 96677-23-5 2,4-Dibrom-1,1,5,5-tetrakis-(4-methoxyphenyl)-penta-1,4-dien 
• 68427-56-5 2-(2'-Chlorophenyl)-1,3-cyclohexanedione 
• 68427-57-6 6-(2',4'-dimethylphenyl)-5-ketohexanoic acid 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 79505-98-9 5-Oxo-5-pentafluorophenyl-pentanoic acid ethyl ester 

Relevant articles and documents

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Preparation method of substituted butyrate derivatives

The invention discloses a preparation method of substituted butyrate derivatives. The method specifically comprises the following steps: by taking compounds shown in a formula 1, a formula 2 and a formula 3 as raw materials, carrying out an illumination reaction process in the presence of a photocatalyst and a hydrogen transfer catalyst to obtain a target compound shown in a formula I through one-step reaction. The invention discloses a free radical-mediated olefin bifunctional reaction without a cyclopropanation intermediate. The reaction can realize a product which can be obtained through cyclopropanation and cyclopropane ring opening processes traditionally in one step. Meanwhile, the preparation method of the compound is simple, uses cheap and easily available compounds as raw materials, and has the beneficial effects of one-step synthesis, mild reaction conditions, fast reaction, low cost, less generated waste, simple and safe operation, high atom economy, high selectivity, extremely wide substrate applicability, high yield and the like.

PROCESS FOR DOUBLE CARBONYLATION OF ALLYL ALCOHOLS TO CORRESPONDING DIESTERS

The invention relates to a process for doubly carbonylating allyl alcohols to the corresponding diesters, wherein a linear or branched allyl alcohol is reacted with a linear or branched alkanol (alcohol) with supply of CO and in the presence of a catalytic system composed of a palladium complex and at least one organic phosphorus ligand and in the presence of a hydrogen halide selected from HCl, HBr and HI.