967-35-1

Usage

InChI:InChI=1/C13H11N3O5/c1-21-11-5-2-9(3-6-11)14-12-7-4-10(15(17)18)8-13(12)16(19)20/h2-8,14H,1H3

Upstream product

• 104-94-9 4-methoxy-aniline 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 119-15-3 4-(2,4-dinitroanilino)phenol 
• 74-88-4 methyl iodide 
• 89-02-1 2,4-dinitrobenzenesulfonic acid 
• 99-65-0 meta-dinitrobenzene 
• 120952-16-1 2-(2,4-dinitrophenoxy)-N-ethylpyridinium tetraphenylborate 
• 70-34-8 2,4-Dinitrofluorobenzene 

Downstream Products

• 33912-19-5 N₁-(4-methoxyphenyl)benzene-1,2,4-triamine 
• 101-64-4 Variamin Blau 
• 54883-79-3 p-anisyl-1 amino-5 benzotriazole 
• 71491-44-6 1-(4-methoxyphenyl)-5-nitro-1H-benzo[d][1,2,3]triazole 
• 71491-45-7 p-anisyl-1 cyano-5 benzotriazole 
• 7104-61-2 1-(4-methoxyphenyl)-5-aminobenzimidazole 
• 1366232-44-1 C₂₃H₂₃N₃O 
• 1366232-46-3 C₂₅H₂₇N₃O 
• 1366232-47-4 C₂₅H₂₇N₃O 
• 1366232-61-2 C₂₅H₂₇N₃O₂ 
• 1366232-62-3 C₂₈H₂₅N₃O 
• 1366232-41-8 C₂₇H₂₃N₃O₂ 
• 1366232-93-0 C₂₅H₂₈N₄O₂ 
• 1366232-69-0 C₂₄H₂₆N₄O 

Relevant academic research and scientific papers

Benzimidazole derivative as well as synthesis method and application thereof

The invention discloses a benzimidazole derivative as well as a synthesis method and application thereof, and relates to the technical field of antiviral therapeutic drugs. According to the benzimidazole derivative as well as the synthesis method and appl

Compound with anti-Lassa virus activity, and preparation method and application thereof

The invention discloses a compound with anti-Lassa virus activity, and a preparation method and application thereof, and relates to the technical field of antiviral therapeutic drugs. The compound is 2, 6-dimethoxy-4-((1-(4-methoxyphenyl)-1h-benzo[d]imida

Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids

A mild, efficient, and eco-friendly method for the synthesis of o-nitroarylamine from o-nitroaryl sulfonic acid via ipso nucleophilic aryl substitution by amine is described. The products have been obtained with good yields at room temperature without the assistance of any metal, activating agent, or toxic oxidant. This method is useful for racemization-free synthesis of N-aryl amino acid esters.

Deep eutectic solvent as an operative media on structure-reactivity relationships

Deep eutectic solvents seem to be environmentally friendly solvents, particularly because they are prepared easily and have very low-vapor pressures under ambient conditions. They are suitable candidates as green solvents for reaction media with special properties. To present this behavior, substitution reactions of some para- and meta-substituted anilines with 1-fluoro-2,4-dinitrobenzene have been spectrophotometrically investigated in varying mole fractions of ethaline as a deep eutectic solvent in dimethyl sulfoxide (DMSO). The measured rate coefficients of the reaction demonstrated a noticeable variation with the increasing mole fraction of ethaline in ethaline-DMSO mixtures. The linear free energy relationship (LFER) of second-order rate coefficients based on Hammett's substituent constants demonstrates a reasonably linear straight line with a negative slope in different mole fractions of ethaline-DMSO mixtures. Another LFER investigation based on the polarity parameters of the media showed a good agreement with hydrogen bond donor and acceptor abilities of the solvent. Non-LFER assay according to the preferential solvation model confirmed differences between the microsphere solvation of the solute molecules and the bulk composition of the solvents.

“Zero VOC” Synthetic Strategy – Aromatic Amination Reactions in Deep Eutectic Solvents

Rising concern for environment hazards resulting from the use of volatile organic compounds (VOCs) is prompting many chemists to use “green” solvents like water, polyethylene glycol, ionic liquids and deep eutectic solvents (DES). With a few notable exceptions, many of these processes still need to use volatile organic solvents for the workup and isolation of products. In the present report, we demonstrate a “zero VOC” protocol which eliminates the need to use organic solvents for any stage of the reaction. As a proof of concept, nucleophilic aromatic substitution reactions of 1-halo-2,4-dinitrobenzene with secondary amines were carried out in deep eutectic solvents. The reaction workup involved the addition of water for separating the product from the DES. Evaporation of water led to recovery of the DES, which exhibited good recyclability. The reaction in deep eutectic solvents was much faster than that in many other solvents, as confirmed by the kinetic studies. An attempt was made to elucidate the origin of this rate enhancement based on analysis activation parameters and correlation with the polarity parameters. The results show that use of deep eutectic solvents can take chemists a step closer towards the “zero VOC” synthetic strategy.

Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates SNAr reactions of heterocycles with arylamines

Small-molecule drug discovery requires reliable synthetic methods for attaching amino compounds to heterocyclic scaffolds. Trifluoroacetic acid-2,2,2-trifluoroethanol (TFA-TFE) is as an effective combination for achieving SNAr reactions between

Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole

A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope glycoprotein (LASV GP) gene incorporated. High-throughput screening resulted in discovery of a h

Reaction kinetics investigation of 1-fluoro-2,4-dinitrobenzene with substituted anilines in ethyl acetate-methanol mixtures using linear and nonlinear free energy relationships

Aromatic nucleophilic substitution reaction of 1-fluoro-2,4-dinitrobenzene with para-substituted and meta-substituted anilines was kinetically investigated in the mixtures of ethyl acetate and methanol at room temperature. The correlation of second-order rate coefficients with Hammett's substituent constants yields a fairly linear straight line with negative slope in different mole fractions of ethyl acetate-methanol mixtures. The measured rate coefficients of the reaction demonstrated a dramatic variation in ethyl acetate-methanol mixtures with the increasing mole fraction of ethyl acetate. Linear free energy relationship (LFER) investigations confirm that polarity has a major effect on the reaction rate whereas the hydrogen-bonding ability of the media has a slight effect on it. Nonlinear free energy relationship based on preferential solvation hypothesis showed differences between the microsphere solvation of the solute and the bulk composition of the solvents, and non-ideal behavior is observed in the trend of the rate coefficients, which cover the LFER results. Copyright

Oxidative arylamination of 1,3-dinitrobenzene and 3-nitropyridine under anaerobic conditions: The dual role of the nitroarenes

1,3-Dinitrobenzene and 3-nitropyridine react with lithium arylamides under anaerobic conditions to produce N-aryl-2,4-dinitroanilines and N-aryl-5-nitropyridin-2-amines, respectively, in 8-42% yields. ARKAT-USA, Inc.

SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION

Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof. R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2' is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofuryhnethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5', R6, R6', R7, R7' are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.