33912-19-5Relevant academic research and scientific papers
Benzimidazole derivative as well as synthesis method and application thereof
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Paragraph 0050; 0053-0054, (2021/08/11)
The invention discloses a benzimidazole derivative as well as a synthesis method and application thereof, and relates to the technical field of antiviral therapeutic drugs. According to the benzimidazole derivative as well as the synthesis method and appl
Compound with anti-Lassa virus activity, and preparation method and application thereof
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Paragraph 0041; 0045; 0048-0049, (2021/08/07)
The invention discloses a compound with anti-Lassa virus activity, and a preparation method and application thereof, and relates to the technical field of antiviral therapeutic drugs. The compound is 2, 6-dimethoxy-4-((1-(4-methoxyphenyl)-1h-benzo[d]imida
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole
Dai, Dongcheng,Burgeson, James R.,Gharaibeh, Dima N.,Moore, Amy L.,Larson, Ryan A.,Cerruti, Natasha R.,Amberg, Sean M.,Bolken, Tove C.,Hruby, Dennis E.
, p. 744 - 749 (2013/02/25)
A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope glycoprotein (LASV GP) gene incorporated. High-throughput screening resulted in discovery of a h
Novel benzimidazole-based MCH R1 antagonists
Carpenter, Andrew J.,Al-Barazanji, Kamal A.,Barvian, Kevin K.,Bishop, Michael J.,Britt, Christy S.,Cooper, Joel P.,Goetz, Aaron S.,Grizzle, Mary K.,Hertzog, Donald L.,Ignar, Diane M.,Morgan, Ronda O.,Peckham, Gregory E.,Speake, Jason D.,Swain, Will R.
, p. 4994 - 5000 (2007/10/03)
The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
