96700-91-3Relevant academic research and scientific papers
WATER-SOLUBLE TRIMETHOXYPHENYLPYRIDINE-TYPE COMPLEXING AGENTS, AND CORRESPONDING LANTHANIDE COMPLEXES
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Paragraph 0080-0081; 0168, (2020/05/29)
The invention relates to complexing agents of formula (I): in which Ra, Chrom1, Chrom2 and Chrom3 are as defined in the description. The invention also relates to lanthanide complexes obtained from these complexing agents.
WATER-SOLUBLE TRIAZAPYRIDINOPHANE-BASED COMPLEXING AGENTS AND CORRESPONDING FLUORESCENT LANTHANIDE COMPLEXES
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Paragraph 0092, (2019/01/04)
The invention relates to complexing agents of formula (I) in which A1, A2, A3 and R1 are as defined in the description. The invention also relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.
3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS
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Page/Page column 29, (2009/10/21)
A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.
Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: Discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist
Sircar, Ila,Gudmundsson, Kristjan S.,Martin, Richard,Liang, Jimmy,Nomura, Sumihiro,Jayakumar, Honnappa,Teegarden, Bradley R.,Nowlin, Dawn M.,Cardarelli, Pina M.,Mah, Jason R.,Connell, Samuel,Griffith, Ronald C.,Lazarides, Elias
, p. 2051 - 2066 (2007/10/03)
α4β1 and α4β7 integrins are key regulators of physiologic and pathologic responses in inflammation and autoimmune disease. The effectiveness of anti-integrin antibodies to attenuate a number of inflammatory/immune conditions provides a strong rationale to target integrins for drug development. Important advances have been made in identifying potent and selective candidates, peptides and peptidomimetics, for further development. Herein, we report the discovery of a series of novel N-benzoyl-L-biphenylalanine derivatives that are potent inhibitors of α4 integrins. The potency of the initial lead compound (1: IC50 α4β7/α4β1 =5/33 μM) was optimized via sequential manipulation of substituents to generate low nM, orally bioavailable dual α4β1/α4β7 antagonists. The SAR also led to the identification of several subnanomolar antagonists (134, 142, and 143). Compound 81 (TR-14035; IC50 α4β7/α4β1 =7/87 nM) has completed Phase I studies in Europe. The synthesis, SAR and biological evaluation of these compounds are described.
Total Synthesis of (+/-)-5-O-Methyllicoricidin
Shih, Thomas L.,Wyvratt, Matthew J.,Mrozik, Helmut
, p. 2029 - 2033 (2007/10/02)
A novel intramolecular Mitsunobu alkylation is employed to construct the benzopyran moiety of the newly isolated isoflavan 5-O-methyllicoricidin.This convergent 15-step total synthesis outlines a chemically mild approach to the acid-sensitive isoflavanoid
Regioselectivity in lithiation of t-butyldimethylsiloxy-3, 5-dimethoxybenzene. A synthesis of the trimethyl ether of sophoraflavanone A
Trost, Berry M.,Saulnier, Mark G.
, p. 123 - 126 (2007/10/02)
Selective metallation by inhibiting the directive effect of an oxygen substituent leads to selective substitution of a trioxygenated benzene and a five step synthesis of the titled potentially anti-fungal natural product.
