96701-35-8

Upstream product

• 86541-14-2 methyl 3-methyl-2-[(3R,4R)-3-(1-hydroxy-1-methylethyl)-2-oxo-4-allylazetidin-1-yl]but-2-enoate 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 80528-05-8 isocyanoazetidinone 
• 86489-13-6 methyl 2-[(3R,4R)-3-(1-hydroxy-1-methylethyl)-3-isocyano-2-oxo-4-allylazetidin-1-yl]-3-methylbut-2-enoate 

Downstream Products

• 86489-42-1 (3R,4R)-4-(2,2-dimethoxyethyl)-3-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-azetidin-2-one 
• 86541-40-4 4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 86541-35-7 {(2R,3R)-3-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-4-oxo-azetidin-2-yl}acetic acid 
• 86541-42-6 4-nitrobenzyl (5R,6R)-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-3-[2-(4-nitrobenzyloxycarbonylamino)ethylthio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 86541-41-5 4-nitrobenzyl (5R,6R)-3-(2-acetamidoethylthio)-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 86489-51-2 4-nitrobenzyl (5R,6R)-3-[(Z)-2-acetamidovinyl-thio]-6-[1-methyl-1-(4-nitrobenzyloxycarbonyloxy)ethyl]-7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate 
• 86541-39-1 4-nitrobenzyl 2-diazo-4-[(2R,3R)-3-{1-methyl-1-(4-nitrobenzyloxycarbonyloxy)-ethyl}-4-oxoazetidin-2-yl]-3-oxobutanoate 

Relevant academic research and scientific papers

SYNTHETIC STUDIES ON CARBAPENEM ANTIBIOTICS FROM PENICILLINS. III. STEREOSELECTIVE RADICAL REDUCTION OF A CHIRAL 3-ISOCYANOAZETIDINONE: A TOTAL SYNTHESIS OF OPTICALLY ACTIVE CARPETIMYCINS

A new, efficient synthesis of the optically active carpetimycins 1 from penicillins has been achieved via, as key steps, aldol reaction of isonitrile 19, followed by n-Bu3SnH reduction.