96715-43-4Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of diversified heterocyclic systems
Bari, Ahmed,Grenier, Daniel,Azelmat, Jabrane,Syed, Saeed Ali,Al-Obaid, Abdulrahman M.,Hosten, Eric C.
, p. 1750 - 1759 (2019)
In continuation with our research program on the development of novel bioactive molecules, we report herein the design and synthesis of a series of diversified heterocycles (4–22). The synthesized compounds were evaluated for their anti-inflammatory activity. The chemical structures of the newly synthesized compounds have been confirmed by NMR, FTIR, and microanalysis.
Eco-friendly synthesis of some thiosemicarbazones and their applications as intermediates for 5-arylazothiazole disperse dyes
Gaffer, Hatem E.,Khalifa, Mohamed E.
, p. 21982 - 21991 (2016/01/25)
The solid-solid reactions of thiosemicarbazide with 4-formylantipyrine, 2-acetylpyrrole and camphor were performed to afford the thiosemicarbazones 1-3 which underwent hetero-cyclization with phenacyl bromide to furnish the corresponding thiazole derivatives 4-6. The yields of the reactions are quantitative in all cases and the products do not require further purification. A series of 5-arylazo-2-(substituted ylidene-hydrazinyl)-thiazole dyes 7-9 was then prepared by diazo coupling of thiazole derivatives 4-6 with several diazonium chlorides. The synthesized dyes were applied as disperse dyes for dyeing polyester fabric. The dyed fabrics exhibit good washing, perspiration, sublimation and light fastness properties, with little variation in their moderate to good rubbing fastness.
