96719-68-5

Basic information

• Product Name: 1,2-bis(3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 96719-68-5
• Molecular Formula: C₂₂H₁₉F₂NO
• Molecular Weight: 351.3892
• Mol File: 96719-68-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 485.6°C at 760 mmHg
• Flash Point: 247.5°C
• Density: 1.219g/cm³
• Vapor Pressure: 1.39E-09mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1,2-bis(3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(96719-68-5)
• EPA Substance Registry System: 1,2-bis(3-fluorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline(96719-68-5)

Safety Data

• Hazardous Substances Data: 96719-68-5(Hazardous Substances Data)

Usage

Chemical structure

A tetrahydroisoquinoline derivative with two 3-fluorophenyl groups and a methoxy group

Fluorine content

Contains two fluorine atoms in the 3-fluorophenyl groups

Methoxy group

Presence of a methoxy (-OCH3) group at the 6-position

Potential pharmaceutical applications

Due to its structural features and properties, it can interact with biological targets and potentially exhibit bioactivity

Research areas

Synthesis, characterization, and potential uses in pharmacology and medicinal chemistry

Bioactivity

May have potential for therapeutic applications based on its ability to interact with biological targets

Further development

Areas of interest for additional research and development in the fields of chemistry and medicine

Upstream product

• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 96719-01-6 3-Fluoro-N-(3-fluoro-phenyl)-N-[2-(3-methoxy-phenyl)-ethyl]-benzamide 
• 96718-68-2 N-(3’-fluorophenyl)-2-(3-methoxyphenyl)acetamide 
• 96718-73-9 3-fluoro-N-(3-methoxyphenethyl)aniline 
• 1798-09-0 m-methoxyphenylacetic acid 

Relevant articles and documents

Antiimplantation Agents: Part II - 1,2-Diaryl-1,2,3,4-tetrahydroisoquinolines

1,2-Diaryl-3,4-dihydroisoquinolinium derivatives (5) have been synthesised from N-aryl-N-aroyl-β-phenethylamines (4) and found to exhibit no antiimplantation activity in the rat whereas many of the corresponding tetrahydroisoquinolines (6) are active.Structure-activity relationships have also been studied. 1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (6u) and its nor derivative (6v) are very potent, while the ortho (6g) and the meta (6n) fluoro analogues as well as the des-fluoro derivative (6d) are quite active.Extensive biological tests have been carried out on 6g.The enantiomers (+)-6p*HCl and (-)-6q*HCl of 6n have similar activity profiles as that of 6n showing no separation of antiimplantation and estrogenic properties.Diastereomeric 2-(2-methyl-2-phenethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolines (13a and 13b) show similar properties, while the tetracyclic derivative 19 is inactive. 2-Phenoxyethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (26) shows moderate activity, but 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 29 is inactive.