96754-91-5Relevant academic research and scientific papers
7-Hydroxy-benzopyran-4-one derivatives: A novel pharmacophore of peroxisome proliferator-activated receptor α and -γ (PPARα and γ) dual agonists
Matin, Azadeh,Gavande, Navnath,Kim, Moon S.,Yang, Nancy X.,Salam, Noeris K.,Hanrahan, Jane R.,Roubin, Rebecca H.,Hibbs, David E.
experimental part, p. 6835 - 6850 (2010/04/04)
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel molecules, exhibiting similarity to the core structure of both fibrates and thiazolidinediones. New lead PPAR ligands were identified from "natraceuticals" and synthetic analogues. In total, 77 molecules, including chalcones, flavones, flavanones, isoflavones, and pyrazole derivatives, were screened and structure-activity relationship studies of the dual agonists undertaken. Compounds 68, 70, 72, and 76 were identified as novel and potent dual PPARα and γ agonists. These novel molecules may have the potential to be the future leads in PPAR-related disorders, including type II diabetes mellitus and metabolic syndrome. 2009 American Chemical Society.
FLAVONOID PPAR AGONISTS
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Page/Page column 36; 67, (2009/04/25)
The present invention relates to PPAR agonists, and their use in therapy including the treatment of disease. In particular, the invention relates to flavonoid compounds which are PPAR-gamma agonists and/or PPAR alpha/gamma dual agonists.
SYNTHETIC AND MODIFIED ISOFLAVONOIDS. III. SYNTHESIS OF BENZODIOXANE ANALOGUES OF PSEUDOBAPTIGENIN
Aitmambetov, A.,Grishko, L. G.,Khilya, V. P.
, p. 720 - 725 (2007/10/02)
Benzodioxane analogues of pseudobaptigenin with alkyl fragments in positions 2 and 6 of the chromone ring have been synthesized from α-(1,4-benzodioxan-6-yl)-2-hydroxy-6-alkylacetophenones.
Mixed Anhydride of Acetic and Formic Acids in the Synthesis of Chromones. 2. Synthesis of 3-Arylchromones
Pivovarenko, V. G.,Khilya, V. P.
, p. 497 - 502 (2007/10/02)
A study was carried out on the reaction of α-substituted 2-hydroxyacetophenones eith the mixed anhydride of acetic and formic acids in the presence of bases of different strength.Chromones containing a conjugated electron-withdrawing substituent at C(3) are formed in close to quantitative yield in the presence of triethylamine.The preparation of chromones containing an unconjugated substituent under these conditions is recommended only for 5-hydroxychromones.
