96756-93-3

Usage

Molecular Structure

1H-Indole, 1-(4-fluorophenyl)-4,5,6,7-tetrahydro-2-phenylconsists of an indole ring with a 4-fluorophenyl group and a phenyl group attached to it.

Tetrahydro Derivative

The compound has four hydrogen atoms added to the indole ring, which influences its properties and reactivity.

Aromatic and Aliphatic Groups

The presence of both aromatic (4-fluorophenyl and phenyl groups) and aliphatic (tetrahydro) groups makes the compound versatile for various chemical and biological processes.

Potential Pharmaceutical Applications

The presence of the 4-fluorophenyl group suggests that 1H-Indole, 1-(4-fluorophenyl)-4,5,6,7-tetrahydro-2-phenyl- may have potential pharmaceutical or medicinal applications.

Complex Structure

The intricate structure of the compound requires further research and analysis to fully understand its properties and potential applications.

Upstream product

• 371-40-4 4-fluoroaniline 
• 932-03-6 1-Ethynyl-7-oxa-bicyclo[4.1.0]heptane 
• 591-50-4 iodobenzene 
• 33553-23-0 2-phenacylcyclohexanone 

Downstream Products

• 96757-13-0 1-(4-Fluoro-phenyl)-3-morpholin-4-ylmethyl-2-phenyl-4,5,6,7-tetrahydro-1H-indole 

Relevant academic research and scientific papers

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1 H -indole as a novel anti-hepatitis C virus targeting scaffold

Although all-oral direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) treatment is now a reality, today's HCV drugs are expensive, and more affordable drugs are still urgently needed. In this work, we report the identification of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole chemical scaffold that inhibits cellular replication of HCV genotype 1b and 2a subgenomic replicons. The anti-HCV genotype 1b and 2a profiling and effects on cell viability of a selected representative set of derivatives as well as their chemical synthesis are described herein. The most potent compound 39 displayed EC50 values of 7.9 and 2.6 μM in genotype 1b and 2a, respectively. Biochemical assays showed that derivative 39 had no effect on HCV NS5B polymerase, NS3 helicase, IRES mediated translation and selected host factors. Thus, future work will involve both the chemical optimization and target identification of 2-phenyl-4,5,6,7-Tetrahydro-1H-indoles as new anti-HCV agents.

Synthesis of 4,5,6,7-tetrahydro-1H-indole derivatives through successive sonogashira coupling/Pd-mediated 5-endo-dig cyclization

A one-pot Sonogashira cross-coupling/5-endo-dig cyclization procedure leading to 2-aryl-4,5,6,7-tetrahydroindoles was developed. This short (only two steps from commercially available compounds) sequence avoids harsh conditions and expensive catalysts. Our procedure is highly tolerant to a range of functional groups (amino, nitro, carboxy, cyano, hydroxy, and bromo). A family of 21 tetrahydroindoles was synthesized on a gram scale in a good to excellent yields, which is indicative of the general character and scalability of this reaction. This methodology allows access to indoles bearing miscellaneous substituents at the C2 position (by variation of ArI) and at the nitrogen atom (by variation of RNH2, including chiral moieties). A one-pot sequence based on Sonogashira cross-coupling/Pd-mediated 5-endo-dig cyclization was developed and applied to the gram-scale synthesis of 2-aryl-4,5,6,7- tetrahydroindoles (21 examples). Copyright

Antiimplantation Agents: Part III - 1,2-Diaryl-4,5-polymethylenepyrroles and 1,2-Diaryl-4-oxo- and 1,2-Diaryl-4-hydroxy-4,5,6,7-tetrahydroindoles

2-Phenacylcycloalkanoles (3) and anilines give rise to polymethylenepyrroles (4).Pyrrolopiperidine (10) is likewise obtained from 2-phenacylpiperidone (9). 2-Phenacylcyclohexane-1,3-diones undergo condensation with anilines to form 1,2-diaryl-4-oxo-4,5,6,