96765-36-5

Upstream product

• 19312-11-9 bis(2,5-dimethoxyphenyl)methane 
• 50874-27-6 1,4-bis(bromomethyl)-2,5-dimethoxybenzene 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 150-78-7 1,4-dimethoxybezene 

Relevant academic research and scientific papers

Step-Growth Cyclo-Oligomerization for the Preparation of Di- and Tetrafunctionalized Pillar[5]arenes

The preparation of complex functionalized pillar[n]arenes (PA[n]s) is challenging by one-pot cocyclization or selective deprotection method. We developed a step-growth cyclo-oligomerization method to synthesize functionalized PA[5]s. Dimers, trimers, and tetramers were synthesized and characterized. With this new method, we were able to prepare three di- and tetrafunctionalized PA[5]s. By using a multistep synthetic strategy, the chance to form constitutional isomers and other by-products was reduced. Therefore, complex tetrafunctionalized PA[5]s were prepared with improved yield.