96780-98-2Relevant academic research and scientific papers
N-heterocyclic carbene-palladium-imine complex catalyzed α-arylation of ketones with aryl and heteroaryl chlorides under air atmosphere
Lu, Hui-Yang,Shen, An,Li, Yong-Qing,Hu, Yu-Cai,Ni, Chen,Cao, Yu-Cai
, (2020)
A new structure of saturated ring skeleton monoligated NHC-Pd-Imine complex was easily synthesized and unambiguously confirmed by X-ray single crystal diffraction. It was found to be an efficient and air-stable catalyst for the α-arylation of ketones. The reaction could be operated in air without any negative effect. Non-activated aryl and heteroaryl chlorides have been successfully applied in the reaction with only 0.5 mol% catalyst loadings under air atmosphere. Excellent to good product yields were afforded.
Pyridazines. XXIII . A Novel Pyridazine into Pyrazole Ring Transformation
Heinisch, Gottfried,Waglechner, Richard
, p. 1727 - 1731 (2007/10/02)
Treatment of phenyl(4-pyridazinyl)methanols 1a and 1b with p-toluenesulfonic acid at elevated temperatures causes transformation into the C-4 substituted pyrazole derivatives 8a and 8b.Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed.Furthemore, the preparation of hitherto unknown 4-pyridazinylmethanols 1b, 3, and 7 is described.
