96791-67-2Relevant academic research and scientific papers
Opposite High Diastereoselectivity in the Carbonyl Addition of Organolithium and Grignard Reagents to 3-Acylisoxazolines
Wade, Peter A.,Price, David T.,McCauley, John P.,Carroll, Patrick J.
, p. 2804 - 2805 (2007/10/02)
The reactions of organolithium and Grignard reagents with 3-acyl-4,5-disubstituted-isoxazolines to produce tertiary alcohols show high but opposite diastereoselectivity; competitive pathways involving attack on s-trans and metal-chelated s-cis conformations of the O=CC=N system are proposed.
