96795-01-6Relevant academic research and scientific papers
A facile and efficient asymmetric synthesis of florfenicol
Li, Feng,Wang, Zhong-Hua,Zhao, Lei,Chen, Fen-Er
supporting information; experimental part, p. 2883 - 2885 (2012/01/11)
A facile and efficient enantioselective synthesis of flor-fenicol starting from commercially available 4-methylthiobenzaldehyde is described. Key features of the synthesis include a one-step oxidation of allyl and thioether groups in allylic alcohol to form (2S,3S)-epoxide under Sharpless epoxidation conditions and a highly efficient conversion of (1R,2R)-azide into amino alcohol via debenzylation and reduction of an azido moiety in one-pot operation. Georg Thieme Verlag Stuttgart. New York.
