96800-34-9

Upstream product

• 150880-20-9 Methanesulfonic acid (R)-2-oxo-3-phenyl-oxazolidin-5-ylmethyl ester 
• 103-71-9 phenyl isocyanate 
• 85820-84-4 (-)-(2S)-3-azidopropane-1,2-diol 
• 62-53-3 aniline 
• 87508-50-7 (R)-3-(phenylamino)-1,2-propanediol 
• 41274-09-3 (R)-3-tosyloxy-1,2-propanediol 
• 239438-44-9 C₂₀H₂₀N₂O₆ 
• 239438-40-5 C₂₃H₂₄N₂O₆ 
• 87508-42-7 (R)-5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine 
• 104392-60-1 (R)-<5-(hydroxymethyl)-3-phenyl-2-oxooxazolidinyl>-methyl 4-methylbenzenesulfonate 

Downstream Products

• 96800-17-8 (S)-N-<<3-phenyl-2-oxo-5-oxazolidinyl>methyl>acetamide 
• 96800-11-2 (S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide 

Relevant academic research and scientific papers

Synthesis of oxazolidinones by a solid-phase/activation cycloelimination (sp/ace) methodology

A versatile method for the solid-phase synthesis of oxazolidinones is described. An appropriate 1,2-diol is attached to immobilized sulfonyl chloride, resulting in the selective activation of one of the alcohol functions. The subsequent reaction of the ot

Polymer-aided stereodivergent synthesis (PASS): A new concept for the discrete preparation of optical antipodes

A new concept to the discrete prepartion of optical antipodes is reported. The approach makes use of a cyclization/cleavage procedure that has been applied to polymer-supported quasi-meso compound 1, containing a polymeric leaving group and a regular leaving group. Two-directional cyclization leads to the formation and separation of quasi-enantiomers 2 and 3 simultaneously, with one being immobilized and on free in solution. Treatment of 2 and 3 with appropriate nucleophiles gives discrete enantiomers 4 and 5.

A short synthesis of oxazolidinone derivatives linezolid and eperezolid: A new class of antibacterials

Oxazolidinone derivatives such as Linezolid and Eperazolid, which are a new class of antibacterials, have been synthesized from 1,2,5,6-dianhydro- 3,4-isopropylidine-D-mannitol in good yield.

Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The 'B' group

The synthesis and structure/activity studies of the effect of varying the 'B' group in a series of oxazolidinone antibacterials (I) are described. Two synthetic routes were used: (1) alkylation of aniline with glycidol followed by dialkyl carbonate heterocyclization to afford I (A = H, B = OH), whose arene ring was further elaborated by using electrophilic aromatic substitution methodology; (2) cycloaddition of substituted aryl isocyanates with epoxides to give A and B with a variety of values. I with B = OH or Br were converted to other 'B' functionalities by using S(N)2 methodology. Antibacterial evaluation of compounds I with A = acetyl, isopropyl, methylthio, methylsulfinyl, methylsulfonyl, and sulfonamido and a variety of different 'B' groups against Staphylococcus aureus and Enterococcus faecalis concluded that the compounds with B = aminoacyl, and particularly acetamido, were the most active of those examined in each A series, possessing MICs in the range of 0.5-4 μg/mL for the most active compounds described.