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Usage

Uses

Used in Pharmaceutical Industry:
1-O-Hexadecyl-2-deoxy-2-thio-S-acetyl-sn-glyceryl-3-phosphorylcholine is used as an antineoplastic agent for its ability to inhibit the synthesis of phosphatidylcholine, disrupt cell membrane integrity, and induce apoptosis in cancer cells. It is particularly effective against leukemia and solid tumors and has potential in the treatment of various types of cancer.
Used in Cancer Research:
1-O-Hexadecyl-2-deoxy-2-thio-S-acetyl-sn-glyceryl-3-phosphorylcholine is used as a research tool to study the mechanisms of cell death and apoptosis in cancer cells, as well as its potential to inhibit angiogenesis, which can help in the development of new cancer therapies and treatment strategies.

Upstream product

• 112025-92-0 Thioacetic acid S-{(R)-2-[(2-bromo-ethoxy)-hydroxy-phosphoryloxy]-1-hexadecyloxymethyl-ethyl} ester 
• 75-50-3 trimethylamine 
• 112014-15-0 1-hexadecyl-2-thioacetyl-2-deoxyglycerol 
• 108-24-7 acetic anhydride 
• 6140-88-1 hexadecane-1-sulfonic acid 
• 89496-73-1 4-(n-hexadecyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 506-03-6 chimyl alcohol 
• 92471-46-0 (R)-3-(1-hexadecyloxy)-1-(trityloxy)propan-2-ol 
• 177167-79-2 Thioacetic acid S-((R)-1-hexadecyloxymethyl-2-trityloxy-ethyl) ester 
• 177167-80-5 (R)-1-Hexadecyloxy-3-trityloxy-propane-2-thiol 
• 177167-81-6 (S)-3-Hexadecyloxy-2-tritylsulfanyl-propan-1-ol 
• 146797-77-5 (S)-3-O-hexadecyl-2-O-(4-nitrobenzenesulfonyl)-1-O-tetrahydropyranylglycerol 
• 146923-48-0 (S)-2-O-benzyl-3-O-hexadecyl-1-O-tetrahydropyranylglycerol 
• 146797-78-6 (R)-1-O-hexadecyl-3-O-tetrahydropyranyl-2-thioacetyl-2-desoxyglycerol 

Relevant academic research and scientific papers

Platelet activating factor derivative and synthesis method thereof

The invention belongs to the technical field of chemical synthesis and discloses a platelet activating factor derivative with a formula (I) structure, wherein a substituent group R refers to an acryl group. A synthetic route includes nine-step reaction by taking chiral source S-configuration solketal as a starting reactant. The method is adopted for synthesis of a 2-sulfo platelet activating factor and a derivative thereof for the first time and has advantages of high yield, easiness in separation and the like. Low-cost batch synthesis of 2-S-PAF and the derivative thereof is realized, and significances to activity research of 2-S-PAF and the derivative thereof, biological experiments, clinical application and disease treatment are achieved.

New synthesis of 2-thio-PAF and related compounds as substrates of PAF acetylhydrolase and phospholipase A2

2-Thio PAF and related compounds (1 a-c) as substrates of PAF acetylhydrolase and phospholipase A2 were synthesized stereoselectively from optically active 2-O-benzylglycerol monoacetate.

STEREOSPECIFIC SYNTHESIS OF PAF ANALOGUES. PREPARATION OF 1-HEXADECYL 2-THIOACETYL-2-DEOXYGLYCEROPHOSPHOCHOLINE (2-THIOPAF)

A new stereospecific synthesis of ether-phospholipids leading to 2-ThioPAF is reported.