96801-89-7Relevant academic research and scientific papers
Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP- specific phosphodiesterase and of malignant tumor cell growth
Merz, Karl-Heinz,Marko, Doris,Regiert, Thomas,Reiss, Guido,Frank, Walter,Eisenbrand, Gerhard
, p. 4733 - 4743 (1998)
7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine (7a) is a potent inhibitor of the cAMP-specific phosphodiesterase isoenzyme family PDE4 and induces growth inhibition in a panel of tumor cell lines. In this study, we describe a synthesis that yi
