96801-85-3Relevant academic research and scientific papers
Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP- specific phosphodiesterase and of malignant tumor cell growth
Merz, Karl-Heinz,Marko, Doris,Regiert, Thomas,Reiss, Guido,Frank, Walter,Eisenbrand, Gerhard
, p. 4733 - 4743 (2007/10/03)
7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine (7a) is a potent inhibitor of the cAMP-specific phosphodiesterase isoenzyme family PDE4 and induces growth inhibition in a panel of tumor cell lines. In this study, we describe a synthesis that yi
2-Piperazino-pteridines useful as antithrombotics and antimetastatics
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; R2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; and R3 is halogen, alkoxy, alkylthio, phenylalkoxy or phenylalkylthio; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics and antimetastatics.
