96803-30-4

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE is used as a reactant in the preparation of 4-aminoquinolines and tetraoxanes, which display antimalarial activity. Its presence in these compounds contributes to their effectiveness in treating malaria, a significant global health concern.
Used in Chemical Synthesis:
As a versatile organic compound, 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE can be employed in various chemical synthesis processes. Its benzo[b]thiophene ring and hydroxyethyl group can be further modified or used as a building block for the development of new compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 75-21-8 oxirane 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 74-88-4 methyl iodide 
• 98820-66-7 benzothiophene-5-acetic acid ethyl ester 
• 17381-51-0 (1-benzothiophen-5-yl)acetonitrile 
• 10133-22-9 5-bromomethyl-benzo[b]thiophene 
• 17381-54-3 (1-benzothiophen-5-yl)acetic acid 

Downstream Products

• 519188-55-7 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propionyl)azetidin-3-ol 
• 519188-42-2 3-(2-(1-benzothiophen-5-yl)ethoxy)propionic acid 

Relevant academic research and scientific papers

2-(1-Benzothiophen-5-yl) production of ethanol

PROBLEM TO BE SOLVED: To provide an excellent production method for 2-(1-benzothiophen-5-yl)ethanol. SOLUTION: There is provided a method for production of 2-(1-benzothiophen-5-yl)ethanol comprising esterifying (1-benzothiophen-5-yl)acetic acid, and performing the reductive reaction of the resultant ester using a boron hydride complex compound in the presence or absence of a metal halide. This is useful as a production method for 2-(1-benzothiophen-5-yl)ethanol, safe for human bodies and environmentally friendly. COPYRIGHT: (C)2011,JPOandINPIT

Construction of polyaromatics via photocyclization of 2-(fur-3-yl) ethenylarenes, using a 3-furyl group as an isopropenyl equivalent synthon

The construction of different types of substituted arenes was demonstrated through the photocyclization of 2-(fur-3-yl)ethenylarenes using a 3-furyl group as an isopropenyl equivalent synthon in the photocyclization reaction. The furan portion of the photocyclization intermediate could be fragmented via a base-induced elimination reaction to yield a series of substituted polyaromatics, including naphthalene, benzofuran, benzothiophene, phenanthrene, phenalene, acenaphthene, and triphenylene. Using different reagents, this method made it possible to introduce methyl or 2-hydroxyethyl groups as substituents at specific positions in these arenes.

PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)- ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF

A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1- benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities

In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and

Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor

Novel 2-sulfamoylbenzo[b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.