96818-15-4

Upstream product

• 96818-12-1 3-(2,4-dimethoxyphenyl)propionyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 96818-10-9 2,4-dimethoxyphenylpropionic acid sodium salt 

Downstream Products

• 92617-50-0 3-allyl(p-chlorophenylthio)amino-2-<2-(4-hydroxy-2-methoxyphenyl)ethyl>quinazolin-4(3H)-one 
• 92617-46-4 3-amino-2-<2-(2,4-dimethoxyphenyl)ethyl>quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Intramolecular Reactions of N-Nitrenes: Oxidation of 3-Amino-2-(2,4-dimethoxyphenylethyl)quinazolin-4(3H)-ones

Oxidation of the N-aminoquinazolones (5) and (6) gave the 1H-azepines (7) and (10) respectively.Boat-to-boat flipping of the azepine ring in compound (7) is slow on the n.m.r. time-scale even at 140 deg C.Heating of compound (10a) in chlorobenzene at 135 deg C brings about interconversion with the stereoisomer (10b) with a minimum free energy barrier of 30 kcal mol -1.Possible reasons for this high barrier to azepine ring inversion are examined.