96824-98-5Relevant academic research and scientific papers
Ni-Catalyzed Reductive Coupling of Alkynes and Amides to Access Multi-Functionalized Indoles
Min, Kwan Hong,Iqbal, Naeem,Cho, Eun Jin
, p. 989 - 994 (2022/02/05)
A nickel-catalyzed reductive coupling of alkynes and amides, followed by base-free transmetalation, proceeded selectively in the presence of an uncommon bidentate primary aminophosphine ligand to access highly functionalized indoles comprising biologically important trifluoromethyl groups and challenging electron-rich alkenyl groups at the 2-and 3-positions, respectively. Indole molecules were installed within natural products or drug molecules under mild conditions, and a trifluoromethylated analogue of a drug molecule (pravadoline) was also synthesized.
A Three-Component Strategy for Benzoselenophene Synthesis under Metal-Free Conditions Using Selenium Powder
Ni, Penghui,Tan, Jing,Zhao, Wenqi,Huang, Huawen,Xiao, Fuhong,Deng, Guo-Jun
, p. 3518 - 3522 (2019/05/24)
An efficient three-component benzoselenophenes formation has been developed from substituted indoles, acetophenones, and selenium powder under metal-free conditions. 2-Aryl indoles played an important role to promote benzoselenophene formation from acetophenone derivatives and selenium powder. One C-C and two C-Se bonds were selectively formed to provide 40 new benzoselenophenes in good yields.
Solid-phase synthesis method of vinyl indole compound
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Paragraph 0030; 0032; 0033; 0034; 0063; 0064, (2019/03/08)
The invention discloses a solid-phase synthesis method of a vinyl indole compound. The solid-phase synthesis method comprises the following steps: step (1): under the protection of nitrogen gas, immersing prepared PSSS (Polystyrene Sodium Sulfonate) resin
Bronsted acid ionic liquid catalyzed facile synthesis of 3-vinylindoles through direct C3 alkenylation of indoles with simple ketones
Taheri, Amir,Liu, Changhui,Lai, Bingbing,Cheng, Cheng,Pan, Xiaojuan,Gu, Yanlong
supporting information, p. 3715 - 3719 (2014/08/05)
A direct dehydrative coupling protocol for the synthesis of 3-vinylindoles using easily available indoles and simple ketones as substrates was developed with the aid of a sulfonyl-containing Bronsted acid ionic liquid. The salient features of this protoco
ELECTRON-TRANSFER PROCESSES: TRANS-SULPHENYLATION OF ELECTRON-RICH SYSTEMS WITH SULPHENAMIDES
Colonna, Martino,Poloni, Marino
, p. 449 - 452 (2007/10/02)
1-Methyl-2-phenylindole, 1-methyl-2-phenyl-3-(α-styryl)indole, as well as indolizinic derivatives, react at room temperature with sulphenamides, affording high yields of compounds sulphenylated either at the pentatomic ring or at the terminal carbon of the side chain.When the reaction is carried out in the cavity of an ESR spectrometer, an unresolved signal is detected which is more intense in the case of indolizinic derivatives.Monoelectronic oxidation of diethylsulphenamide leads to the observation of an ESR spectrum which, after interpretation, was assigned to the corresponding radical cation.
