96851-01-3

Upstream product

• 64-19-7 acetic acid 
• 96947-34-1 6β-benzyloxycarbonylamino-1ξ-oxo-1λ⁴-penicillanic acid methyl ester 

Downstream Products

• 83879-99-6 methyl 2-((3S,4S)-4-acetoxy-3-benzyloxycarbonylaminoazetidin-2-on-1-yl)-3-methylbut-2-enoate 
• 96851-04-6 ((2S,3S)-2-Acetoxy-3-benzyloxycarbonylamino-4-oxo-azetidin-1-yl)-oxo-acetic acid methyl ester 
• 75666-47-6 (3S,4S)-3-benzyloxycarbonylamino-4-acetoxy-azetidin-2-one 
• 80082-81-1 benzyl N-[(3S)-2-oxoazetidin-3-yl]carbamate 

Relevant academic research and scientific papers

Reduction process for the preparation of 4-unsubstituted azetidin-2-ones

Novel process for the preparation of azetidin-2-ones of the formula STR1 wherein R1 and R2 independently from each other are hydrogen, or an organic group linked to the ring carbon via a carbon atom, a nitrogen atom or an oxygen atom, characterized in that a corresponding 4-acyloxyazetidin-2-one, which is substituted by a group --O--CO--R3 at the 4-position, wherein R3 is hydrogen or an organic radical stable at the reaction conditions, is reacted with a complex metal hydride comprising reactive hydride ions, such as, lithium borohydride, sodium borohydride, potassium borohydride, zinc borohydride or tetraorganoammonium borohydride.

A NOVEL PREPARATION OF 4-UNSUBSTITUTED β-LACTAMS

The key intermediate (1) for monobacyam synthesis has been prepared from 6-aminopenicillanic acid (6-APA) without using Raney nickel.Desulfurization was accomplished by a two step process, involving a novel reduction reaction.